More N, Lobosotomayor G, Basse-Cathalinat B, Bedin C, Balabaud C
Am J Physiol. 1984 Apr;246(4 Pt 1):G331-4. doi: 10.1152/ajpgi.1984.246.4.G331.
With indirect methods, it was shown in rats with portacaval shunts (PCS) that total hepatic blood flow (THBF) remained constant when expressed per gram of liver. These results implied an absolute increase in hepatic arterial blood flow (HABF). The aim of this study was to investigate HABF and splanchnic nonhepatic arterial blood flow (SNHABF) with a direct method (57Co microspheres) in PCS rats. One month after surgery, the following results were obtained in PCS rats compared with pair-fed, sham-operated rats: 1) liver mass atrophy was 42.3 +/- 10.9%, 2) HABF (ml X min-1 X g liver-1) was increased by a factor of 2.7, 3) SNHABF (ml X min-1 X 100 g body wt-1) was higher (9.8 +/- 3.3 vs. 5.6 +/- 2.7) (P less than 0.05) and 4) THBF (ml X min-1 X g liver-1) was decreased (1.36 +/- 0.34 vs. 1.85 +/- 0.86) but not significantly. Increases in HABF and SNHABF were not the direct consequence of an increase in cardiac output as attested by a normal cerebral blood flow (ml X min-1 X g organ-1) in PCS rats. In PCS rats, an increase in HABF may prevent the further spread of liver necrosis. The cause and the reason for an increase in SNHABF remain unknown.
采用间接方法研究了门腔分流（PCS）大鼠，结果显示，以每克肝脏计算，其肝总血流量（THBF）保持恒定。这些结果表明肝动脉血流量（HABF）出现了绝对增加。本研究旨在采用直接方法（57Co微球）研究PCS大鼠的HABF和内脏非肝动脉血流量（SNHABF）。术后1个月，与配对饲养的假手术大鼠相比，PCS大鼠获得了以下结果：1）肝脏重量萎缩42.3±10.9%，2）HABF（ml·min-1·g肝脏-1）增加了2.7倍，3）SNHABF（ml·min-1·100g体重-1）更高（9.8±3.3对5.6±2.7）（P<0.05），4）THBF（ml·min-1·g肝脏-1）降低（1.36±0.34对1.85±0.86）但差异不显著。PCS大鼠脑血流量（ml·min-1·g器官-1）正常，证明HABF和SNHABF的增加并非心输出量增加的直接结果。在PCS大鼠中，HABF的增加可能会阻止肝坏死的进一步扩散。SNHABF增加的原因尚不清楚。
