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[拉丁美洲一家医院中心肌梗死所致心源性休克的当前特征及死亡风险因素]

[Current Features and Mortality Risk Factors in Cardiogenic Shock due to Myocardial Infarction in a Latin-American hospital].

作者信息

Guzmán-Rodríguez Rosario, Polo-Lecca Gracia, Aráoz-Tarco Ofelia, Alayo-Lizana Carlos, Chacón-Diaz Manuel

机构信息

Servicio de Cardiología Clínica, Instituto Nacional Cardiovascular INCOR. Lima, Perú. Servicio de Cardiología Clínica Instituto Nacional Cardiovascular INCOR Lima Perú.

出版信息

Arch Peru Cardiol Cir Cardiovasc. 2020 Dec 31;1(4):206-214. doi: 10.47487/apcyccv.v1i4.89. eCollection 2020 Oct-Dec.

Abstract

OBJECTIVE

To know the clinical characteristics and determine the related factors to higher in-hospital mortality in patients with cardiogenic shock (CS) due to myocardial infarction in a Peruvian reference hospital.

MATERIALS AND METHODS

. We conducted a prospective single-center cohort study, to evaluate the clinical characteristics, treatment, and complications of patients with CS due to myocardial infarction from March 2019 to August 2020 at the Instituto Nacional Cardiovascular INCOR. Factors related to higher in-hospital mortality and during follow-up were evaluated. Also, the IABP shock II score was applied to stratify the cohort.

RESULTS

Forty patients were included in the study, 75% of cases were due to left ventricular dysfunction, most of the men and with a median age of 75 (69-82) years. Fifty percent of cases presented CS after admission to the emergency room. Patients stratified by the IABP shock II score as low, intermediate, and high risk, had in-hospital mortality of 37.5%, 71.4%, and 91.6% respectively. In a hospital, mortality was 70%, higher in women, in those over 75 years old, and in those who developed CS during their hospitalization. Serum lactate > 4 mmol/L in univariate analysis was associated with higher mortality risk (HR: 2.8; IC:1.6-3.6, p=0.009). Survival to the end of the study was 12.8%.

CONCLUSIONS

CS due to myocardial infarction is a clinical entity with high mortality in spite of revascularization and the available treatment in our reality. The highest mortality predictor was the serum lactate at admission > 4 mmol/L. The IABP shock II score showed to be an accurate parameter to stratify the death risk in our population.

摘要

目的

了解秘鲁一家参考医院中因心肌梗死导致心源性休克(CS)患者的临床特征,并确定与较高院内死亡率相关的因素。

材料与方法

我们进行了一项前瞻性单中心队列研究,以评估2019年3月至2020年8月在国家心血管研究所(INCOR)因心肌梗死导致CS患者的临床特征、治疗及并发症。评估了与较高院内死亡率及随访期间相关的因素。此外,应用IABP休克II评分对队列进行分层。

结果

40例患者纳入研究,75%的病例因左心室功能障碍所致,大多数为男性,中位年龄75(69 - 82)岁。50%的病例在急诊室入院后出现CS。根据IABP休克II评分分层为低、中、高风险的患者,院内死亡率分别为37.5%、71.4%和91.6%。在医院中,死亡率为70%,女性、75岁以上患者及住院期间发生CS的患者死亡率更高。单因素分析中血清乳酸>4 mmol/L与较高死亡风险相关(HR:2.8;IC:1.6 - 3.6,p = 0.009)。研究结束时的生存率为12.8%。

结论

尽管进行了血运重建及我们现有治疗,因心肌梗死导致的CS仍是一种死亡率高的临床病症。入院时血清乳酸>4 mmol/L是最高的死亡预测因素。IABP休克II评分显示是对我们人群死亡风险进行分层的准确参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b00/10804818/c0b9eb962376/apcyccv-1-206-gf1.jpg

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