Courchesne E, Hesselink J R, Jernigan T L, Yeung-Courchesne R
Arch Neurol. 1987 Mar;44(3):335-41. doi: 10.1001/archneur.1987.00520150073028.
Recent studies of infantile autism using computed tomographic scanning emphasized the importance of studying cases of classic autism (Kanner's syndrome) without complicating conditions such as mental retardation. Computed tomographic scan studies of such patients reported no evidence of anatomical abnormalities of cerebral hemispheres or of subcortical structures, which are defined by landmarks such as the lateral ventricles and lentiform nuclei. Examination of the cerebellum was not mentioned. The most recent postmortem neuropathologic study reported significant cerebellar abnormality, but the study was of a severely retarded autistic individual. Using magnetic resonance imaging, we have found in vivo evidence of a significant and unusual cerebellar malformation in a person with the classic form of autism uncomplicated by mental retardation (current nonverbal IQ = 112), epilepsy, history of drug use, postnatal trauma, or disease. The finding showed hypoplasia of the declive, folium, and tuber in posterior vermis, but not of the anterior vermis, and hypoplasia of only the medial aspect of each cerebellar hemisphere. The right posterior cerebral hemisphere also showed pathologic findings.
近期利用计算机断层扫描对婴幼儿自闭症进行的研究强调了研究典型自闭症（坎纳综合征）病例而不伴有智力迟钝等复杂情况的重要性。对这类患者的计算机断层扫描研究报告称，没有证据表明大脑半球或皮质下结构存在解剖学异常，这些结构由侧脑室和豆状核等标志来界定。未提及对小脑的检查。最新的尸检神经病理学研究报告了明显的小脑异常，但该研究针对的是一名重度智力迟钝的自闭症个体。利用磁共振成像，我们在一名患有典型自闭症且未伴有智力迟钝（目前非言语智商 = 112）、癫痫、吸毒史、产后创伤或疾病的患者体内发现了明显且异常的小脑畸形证据。该发现显示小脑蚓部后部的斜坡、小叶和小结发育不全，但前部蚓部未发育不全，且每个小脑半球仅内侧部分发育不全。右侧大脑后半球也显示出病理结果。
