Zhang Jinwei
Institute of Biomedical and Clinical Sciences, Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
State Key Laboratory of Chemical Biology, Research Center of Chemical Kinomics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Gut Microbes. 2024 Jan-Dec;16(1):2307581. doi: 10.1080/19490976.2024.2307581. Epub 2024 Jan 26.
The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut bacteria in these conditions remain enigmatic. This commentary not only highlights the findings of a recent multi-omics study by Takeuchi et al. but also offers a unique perspective by integrating personal opinions and insights. The discussion revolves around the intricate connection between gut microbes and IR, suggesting novel therapeutic potential in targeting gut microbial carbohydrate metabolism for improved IR management and metabolic health.
肠道微生物群在胰岛素抵抗（IR）、代谢综合征（MetS）和2型糖尿病（T2DM）中的作用正迅速得到认可。然而，肠道细菌在这些病症中的机制和影响仍不清楚。这篇评论不仅突出了竹内等人最近一项多组学研究的结果，还通过整合个人观点和见解提供了独特的视角。讨论围绕肠道微生物与IR之间的复杂联系展开，表明针对肠道微生物碳水化合物代谢以改善IR管理和代谢健康具有新的治疗潜力。
