Liberty Iche Andriyani, Hanifah Laily, Rachmat Hanna Farida, Putri Aidi Alifia, Pratiwi Dessy, Pramono Andri Pramesyanti, Idris Fachmi, Tjekyan Suryadi
Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia.
Department of Public Health Sciences, Faculty of Public Health, Universitas Sriwijaya, Palembang, Indonesia.
Front Nutr. 2025 Apr 16;12:1577528. doi: 10.3389/fnut.2025.1577528. eCollection 2025.
Prediabetes is defined by blood glucose levels that are higher than normal but below the diagnostic threshold for diabetes. Environmental factors associated with diabetes may contribute to its development through alterations in the gut microbiota. Recent studies suggest that changes in the composition and function of the gut microbiota play a role in the pathogenesis of diabetes mellitus and other metabolic disorders.
This study aims to systematically examine taxonomic abundance and its implications in the gut microbiota of individuals with prediabetes, identify key dysbiotic patterns, and explore their potential role in inflammation, insulin resistance, and progression to type 2 diabetes.
We conducted a systematic literature review following PRISMA guidelines. The review included sources from PubMed, ClinicalKey, ScienceDirect, Springer, and Scopus. We retrieved original research articles published in English that focused on prediabetes and gut microbiota from 2015 to the date of our search. Out of 827 full-text articles screened, 6 were selected based on defined inclusion and exclusion criteria.
Dysbiosis of the gut microbiota in prediabetes is characterized by a reduction in butyrate-producing bacteria such as and , along with an increase in potentially harmful taxa such as and species. This imbalance is associated with systemic inflammation and insulin resistance, evidenced by elevated levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and lipopolysaccharide-binding protein (LBP). Increased intestinal permeability facilitates the translocation of bacterial components such as lipopolysaccharides (LPS), further linking gut microbiota changes to the development of insulin resistance and type 2 diabetes.
This review highlights the need for further research to explore the potential therapeutic role of gut microbiota in prediabetes.
Prospero; Identifier CRD42025637369.
糖尿病前期的定义是血糖水平高于正常但低于糖尿病的诊断阈值。与糖尿病相关的环境因素可能通过肠道微生物群的改变促进其发展。最近的研究表明，肠道微生物群的组成和功能变化在糖尿病和其他代谢紊乱的发病机制中起作用。
本研究旨在系统检查糖尿病前期个体肠道微生物群的分类丰度及其影响，识别关键的生态失调模式，并探索它们在炎症、胰岛素抵抗和进展为2型糖尿病中的潜在作用。
我们按照PRISMA指南进行了系统的文献综述。该综述包括来自PubMed、ClinicalKey、ScienceDirect、Springer和Scopus的来源。我们检索了2015年至搜索日期以英文发表的专注于糖尿病前期和肠道微生物群的原始研究文章。在筛选的827篇全文文章中，根据定义的纳入和排除标准选择了6篇。
糖尿病前期肠道微生物群的生态失调表现为产丁酸细菌（如[具体细菌名称1]和[具体细菌名称2]）减少，同时潜在有害类群（如[具体细菌名称3]和[具体细菌种类4]）增加。这种失衡与全身炎症和胰岛素抵抗相关，C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和脂多糖结合蛋白（LBP）水平升高证明了这一点。肠道通透性增加促进了细菌成分如脂多糖（LPS）的易位，进一步将肠道微生物群变化与胰岛素抵抗和2型糖尿病的发展联系起来。
本综述强调需要进一步研究以探索肠道微生物群在糖尿病前期的潜在治疗作用。
Prospero；标识符CRD42025637369。
