Chen Feixiang, Zhang Xinxin, Wang Junxiang, Wang Fukai, Mao Jinlong
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Experimental Center of Shandong University of Traditional Chinese Medicine, Jinan, China.
Curr Top Med Chem. 2024;24(5):416-436. doi: 10.2174/0115680266276823231230183519.
P-coumaric acid is an important phenolic compound that is mainly found in fruits, vegetables, grains, and fungi and is also abundant in Chinese herbal medicines. In this review, the pharmacological research progress of p-coumaric acid in recent years was reviewed, with emphasis on its role and mechanism in oxidative stress-related diseases, such as inflammation, cardiovascular diseases, diabetes, and nervous system diseases. Studies have shown that p-coumaric acid has a positive effect on the prevention and treatment of these diseases by inhibiting oxidative stress. In addition, p-coumaric acid also has anti-tumor, antibacterial, anti-aging skin and other pharmacological effects. This review will provide reference and inspiration for further research on the pharmacological effects of p-coumaric acid.
对香豆酸是一种重要的酚类化合物，主要存在于水果、蔬菜、谷物和真菌中，在中草药中也含量丰富。本文综述了近年来对香豆酸的药理研究进展，重点阐述了其在氧化应激相关疾病（如炎症、心血管疾病、糖尿病和神经系统疾病）中的作用及机制。研究表明，对香豆酸通过抑制氧化应激对这些疾病的防治具有积极作用。此外，对香豆酸还具有抗肿瘤、抗菌、抗皮肤衰老等药理作用。本文综述将为进一步研究对香豆酸的药理作用提供参考和启示。
