Faculty of Medicine, Department of Medical Biology, Hacettepe University, Ankara, Turkey.
Faculty of Medicine, Department of Medical Biology, Niğde Ömer Halisdemir University, Niğde, Turkey.
Mol Biol Rep. 2024 Jan 27;51(1):214. doi: 10.1007/s11033-023-09153-2.
The Golgi complex is a highly dynamic and tightly regulated cellular organelle with essential roles in the processing as well as the sorting of proteins and lipids. Its structure undergoes rapid disassembly and reassembly during normal physiological processes, including cell division, migration, polarization, differentiation, and cell death. Golgi dispersal or fragmentation also occurs in pathological conditions, such as neurodegenerative diseases, infectious diseases, congenital disorders of glycosylation diseases, and cancer. In this review, current knowledge about both structural organization and morphological alterations in the Golgi in physiological and pathological conditions is summarized together with the methodologies that help to reveal its structure.
高尔基体是一种高度动态且受到严格调控的细胞细胞器，在蛋白质和脂质的加工以及分拣中发挥着重要作用。在正常的生理过程中，包括细胞分裂、迁移、极化、分化和细胞死亡，高尔基体的结构会迅速解体和重新组装。在病理条件下，如神经退行性疾病、传染病、先天性糖基化疾病和癌症，高尔基体也会分散或碎裂。本文综述了高尔基体在生理和病理条件下的结构组织和形态变化的最新知识，并介绍了有助于揭示其结构的方法学。
