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[继发性脊髓空洞症的发病机制与治疗]

[Pathogenesis and the treatment of secondary syringomyelia].

作者信息

Nagahiro S, Matsukado Y, Hirata Y, Saito Y, Hamada J, Fukumura A, Itoyama Y

出版信息

No To Shinkei. 1987 Feb;39(2):143-9.

PMID:3828149
Abstract

Six cases with secondary syringomyelia were evaluated clinically and the pathogenesis was discussed. Three cases had the tumors; an ependymoma arising from the conus medullaris and the filum terminale, a foramen magnum meningioma extending to C2 and a thoracic astrocytoma. Two cases had past history of spinal cord injury with L1 and L2 fracture-dislocation, respectively. One case showed hydromyelic symptoms associated with isolated fourth ventricle after post-meningitic hydrocephalus. Clinical symptoms and signs were complex and various in each case due to the association of the original disease and the syrinx. Syringomyelic symptoms were dominant in three cases of which the syrinx extended from the conus to the cervical cord. Initial symptoms of two cases with post-traumatic syringomyelia were tingling pains which began near the site of injury and extended rostrally. Metrizamide myelography revealed complete or incomplete block at the location of the tumors or the injuries. Delayed CT demonstrated the syrinx in all cases. The syrinx was always present near the sites of primary lesions. The communication between the syrinx and the fourth ventricle was suspected in three cases, and the communication of the syrinx and the spinal subarachnoid space was suspected in two cases. All cases underwent the surgical treatments. Total removal of the tumors were completed in two cases and relieved the majority of symptoms. On the other hand, a case with a thoracic astrocytoma underwent biopsy of the tumor and irradiation, followed by poor outcome. Syringo-peritoneal shunts were performed in two cases with post-traumatic syringomyelia and relieved pain, but neurological signs were unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对6例继发性脊髓空洞症患者进行了临床评估并探讨了其发病机制。3例患有肿瘤,分别为起源于圆锥和终丝的室管膜瘤、延伸至C2的枕骨大孔脑膜瘤和胸段星形细胞瘤。2例分别有L1和L2骨折脱位的脊髓损伤病史。1例在脑膜炎后脑积水后出现与孤立性第四脑室相关的积水性脊髓病症状。由于原发病与脊髓空洞症的关联,各病例的临床症状和体征复杂多样。3例脊髓空洞症症状占主导,其中脊髓空洞从圆锥延伸至颈髓。2例创伤后脊髓空洞症患者的初始症状为刺痛,始于损伤部位并向头端延伸。甲泛葡胺脊髓造影显示在肿瘤或损伤部位有完全或不完全梗阻。延迟CT在所有病例中均显示出脊髓空洞。脊髓空洞总是出现在原发病变部位附近。3例怀疑脊髓空洞与第四脑室相通,2例怀疑脊髓空洞与脊髓蛛网膜下腔相通。所有病例均接受了手术治疗。2例完成了肿瘤全切,大部分症状得到缓解。另一方面,1例胸段星形细胞瘤患者接受了肿瘤活检和放疗,预后较差。2例创伤后脊髓空洞症患者进行了脊髓空洞 - 腹腔分流术,疼痛缓解,但神经体征未改变。(摘要截取自250字)

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