Department of Genetics & Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, 8174673461, Isfahan, Iran.
Institute for Medical Informatics & Biometry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, 01307, Germany.
Epigenomics. 2024 Feb;16(3):159-173. doi: 10.2217/epi-2023-0213. Epub 2024 Jan 29.
Enhancer RNAs (eRNAs) are involved in gene expression regulation. Although functional roles of eRNAs in the pathophysiology of neoplasms have been reported, their involvement in gastric cancer (GC) is less known. A network-based integrative approach was utilized for analyzing transcriptome and epigenome alterations in GC, and an eRNA was selected for experimental validation. Survival analysis and clinicopathological associations were also performed. A hub eRNA, , showed significantly increased expression in tumor versus nontumor tissues, as well as an association with clinicopathological features. A seven-gene prognostic model was also constructed. The constructed network provides a comprehensive understanding of the underlying processes implicated in the progression of GC, along with a starting point from which to derive potential diagnostic/prognostic biomarkers.
增强子 RNA（eRNAs）参与基因表达调控。尽管已有研究报道 eRNAs 在肿瘤病理生理学中的功能作用，但它们在胃癌（GC）中的作用知之甚少。本研究采用基于网络的综合方法分析 GC 中的转录组和表观基因组改变，并选择 eRNA 进行实验验证。还进行了生存分析和临床病理关联分析。一个枢纽 eRNA ，在肿瘤与非肿瘤组织中表达显著增加，与临床病理特征相关。还构建了一个七基因预后模型。该构建的网络提供了对 GC 进展中涉及的潜在过程的全面理解，并为潜在的诊断/预后生物标志物提供了起点。
