Lupan Iulia, Bintintan Vasile, Deleanu Diana, Samasca Gabriel
Department of Molecular Biology, Babes-Bolyai University, 400084 Cluj-Napoca, Romania.
Department of Surgery 1, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Biomedicines. 2024 Sep 3;12(9):2001. doi: 10.3390/biomedicines12092001.
Gastric cancer (GC) remains a significant public health concern because of its lethality, underscoring the need for deeper insights into its molecular mechanisms. Recent studies have increasingly highlighted the role of epigenetic modifications as critical players in cancer progression. Despite their importance, research specifically addressing epigenetic factors in GC is relatively scarce. This paper seeks to bridge that gap by examining recent literature that elucidates the epigenetic landscape associated with GC. The investigation of long noncoding RNAs (lncRNAs) has revealed their substantial involvement in gene dysregulation and epigenetic alterations within GC tumors. Notably, lncRNAs such as LINC00853 and LINC01266 have been identified as significant contributors to the epigenetic modulation of gene expression. Furthermore, the overexpression of and has been shown to mitigate the antiproliferative effects resulting from the depletion of circRHOT1, suggesting a complex interplay between these molecules in GC pathophysiology. Another pivotal aspect of epigenetic regulation in GC involves modifications in N6-methyladenosine (m6A), which play crucial roles in mRNA maturation processes such as splicing, export, degradation, and translation. m6A modifications are known for their influence on various cancer-related pathways, thus presenting a potential avenue for targeted interventions. Our findings indicate that the most pronounced instances of epigenetic dysregulation in GC can be traced back to the effects of long lncRNAs and alterations in m6A modification patterns. This underscores the urgent need for comprehensive investigations into these epigenetic factors, as a deeper understanding could lead to enhanced diagnostic markers and innovative therapeutic strategies. The integration of genetic and epigenetic considerations is essential for advancing the field of GC research. This synthesis of recent findings concerning epigenetic regulation offers valuable insights that could inform future studies and therapeutic developments. There is a critical need for ongoing research to elucidate the complexities of epigenetic modifications in GC, ultimately improving patient outcomes through tailored interventions.
胃癌（GC）因其致死性仍然是一个重大的公共卫生问题，这凸显了深入了解其分子机制的必要性。最近的研究越来越强调表观遗传修饰在癌症进展中作为关键因素的作用。尽管它们很重要，但专门针对GC中表观遗传因素的研究相对较少。本文旨在通过研究阐明与GC相关的表观遗传格局的最新文献来弥补这一差距。对长链非编码RNA（lncRNAs）的研究表明，它们在GC肿瘤内的基因失调和表观遗传改变中大量参与。值得注意的是，诸如LINC00853和LINC01266等lncRNAs已被确定为基因表达表观遗传调控的重要贡献者。此外，[此处原文缺失具体分子名称]的过表达已被证明可减轻因circRHOT1缺失导致的抗增殖作用，这表明这些分子在GC病理生理学中存在复杂的相互作用。GC表观遗传调控的另一个关键方面涉及N6-甲基腺苷（m6A）修饰，其在mRNA成熟过程如剪接、输出、降解和翻译中起关键作用。m6A修饰因其对各种癌症相关途径的影响而闻名，因此为靶向干预提供了一条潜在途径。我们的研究结果表明，GC中最明显的表观遗传失调情况可追溯到长lncRNAs的影响和m6A修饰模式的改变。这凸显了对这些表观遗传因素进行全面研究的迫切需求，因为更深入的理解可能会带来更好的诊断标志物和创新的治疗策略。整合遗传和表观遗传因素对于推进GC研究领域至关重要。这种对表观遗传调控最新发现的综合提供了有价值的见解，可为未来的研究和治疗发展提供参考。迫切需要进行持续研究以阐明GC中表观遗传修饰的复杂性，最终通过量身定制的干预改善患者预后。
