Li Zehua, Lu Yao, Yang Li
Renal Division, Peking University Institute of Nephrology, Peking University First Hospital, Beijing, China.
Key Laboratory of Renal Disease-Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment (Peking University)-Ministry of Education of China, Peking University First Hospital, Beijing, China.
Med Rev (2021). 2024 Jan 5;3(6):514-520. doi: 10.1515/mr-2023-0046. eCollection 2023 Dec.
The kidneys are susceptible to a range of insults that can cause damage to them. Early diagnosis, timely prevention, and proper treatment are crucial for improving the outcome of kidney injury. However, the complexity of renal structure and function makes it difficult to reach the demand of early detection and comprehensive evaluation of kidney injury. No successful drug therapy caused by the elaborate pathogenesis mechanism network of kidney injury calls for a systematical interpretation in mechanism researches. Recent advances in renal imaging and omics studies have provided novel views and deeper insights into kidney injury, but also raise challenges in reaching a comprehensive cellular and molecular atlas of kidney injury. Progresses in imaging and omics of kidney injury are being made in various directions, with the initiative of construction a high-resolution structural atlas of kidney, dynamic and non-invasive evaluation of renal function, and systematic establishment of spatially resolved molecular atlas by transcriptomics and metabolomics. With the limitations of a single modality, novel multimodal integration technologies of imaging and omics are being attempted to achieve a systematic description of nephropathy mechanisms. Further extensive efforts in renal multimodal imaging and omics studies are extremely required to deepen our understanding on kidney injury in the context of diagnostic, mechanistic and therapeutic perspectives.
肾脏易受到一系列可导致其损伤的损害。早期诊断、及时预防和恰当治疗对于改善肾损伤的预后至关重要。然而，肾脏结构和功能的复杂性使得难以满足肾损伤早期检测和综合评估的需求。肾损伤复杂的发病机制网络导致尚无成功的药物治疗方法，这就需要在机制研究中进行系统阐释。肾脏成像和组学研究的最新进展为肾损伤提供了新的视角和更深入的见解，但在构建全面的肾损伤细胞和分子图谱方面也带来了挑战。肾损伤成像和组学在多个方向取得了进展，包括构建肾脏高分辨率结构图谱、对肾功能进行动态和非侵入性评估，以及通过转录组学和代谢组学系统建立空间分辨分子图谱。鉴于单一模式的局限性，人们正在尝试新的成像和组学多模态整合技术，以实现对肾病机制的系统描述。在肾脏多模态成像和组学研究方面需要进一步广泛努力，以便从诊断、机制和治疗角度加深我们对肾损伤的理解。
