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胆固醇喂养兔体内富含脂质斑块的血管内光声成像存活研究

Survival intravascular photoacoustic imaging of lipid-rich plaque in cholesterol fed rabbits.

作者信息

Zhang Yi, Taylor Erik, Huang Nasi, Hamilton James, Cheng Ji-Xin

机构信息

Department of Physics, Boston University, Boston, 02215, USA.

Department of Physiology and Biophysics, Boston University School of Medicine, Boston, 02118, USA.

出版信息

Transl Biophotonics. 2022 Dec;4(4). doi: 10.1002/tbio.202200012. Epub 2022 Sep 4.

DOI:10.1002/tbio.202200012
PMID:38283396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10812843/
Abstract

Intravascular photoacoustic (IVPA) imaging is a promising modality for quantitative assessment of lipid-laden atherosclerotic plaques. Yet, survival IVPA imaging of the same plaque in the same animal is not demonstrated. Here, using a sheathed IVUS/PA catheter of 0.9 mm in diameter, we demonstrate MRI-guided survival IVPA imaging of same plaque in an aorta of a well-established rabbit model mimicking atherosclerosis in human patients. The IVUS/PA results were confirmed by histology. These advances open the opportunity to evaluate the effectiveness of a therapy that aims to reduce the size of atherosclerotic plaques and demonstrates the potential of translating the IVPA catheter into clinic for detection of lipid-rich plaques that are at high risk for thrombosis.

摘要

血管内光声（IVPA）成像对于定量评估富含脂质的动脉粥样硬化斑块是一种很有前景的方法。然而，在同一动物体内对同一斑块进行存活期IVPA成像尚未得到证实。在此，我们使用直径为0.9毫米的鞘内IVUS/PA导管，在一个模拟人类患者动脉粥样硬化的成熟兔模型的主动脉中，展示了MRI引导下对同一斑块的存活期IVPA成像。IVUS/PA结果通过组织学得到证实。这些进展为评估旨在减小动脉粥样硬化斑块大小的治疗效果提供了机会，并证明了将IVPA导管转化应用于临床以检测具有高血栓形成风险的富含脂质斑块的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/3afb18ff008e/nihms-1915841-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/932ecc4c8429/nihms-1915841-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/527436f9b7d8/nihms-1915841-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/e51dc7e08c6d/nihms-1915841-f0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/932ecc4c8429/nihms-1915841-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/6a947e55d391/nihms-1915841-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/527436f9b7d8/nihms-1915841-f0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58d/10812843/3afb18ff008e/nihms-1915841-f0006.jpg

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intravascular photoacoustic imaging at a high speed of 100 frames per second.每秒100帧的高速血管内光声成像。
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Tapered fiber-based intravascular photoacoustic endoscopy for high-resolution and deep-penetration imaging of lipid-rich plaque.
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