Piao Zhonglie, Ma Teng, Li Jiawen, Wiedmann Maximilian T, Huang Shenghai, Yu Mingyue, Kirk Shung K, Zhou Qifa, Kim Chang-Seok, Chen Zhongping
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California , Los Angeles, California 90089, USA.
Beckman Laser Institute, Department of Biomedical Engineering, University of California , Irvine, Irvine, California 92612, USA.
Appl Phys Lett. 2015 Aug 24;107(8):083701. doi: 10.1063/1.4929584. Epub 2015 Aug 26.
Intravascular photoacoustic imaging at 1.7 m spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
1.7微米光谱波段的血管内光声成像在检测富含脂质的易损动脉粥样硬化斑块方面已显示出有前景的能力。在这项工作中，我们报告了一种基于导管的高速集成血管内光声/血管内超声（IVPA/IVUS）成像系统，该系统配备了一台波长为1725纳米、频率为500赫兹的光学参量振荡器激光器。用脂质模拟体模和动脉粥样硬化兔腹主动脉进行成像，每秒1帧，这比之前报道的相同波长IVPA成像速度快两个数量级。通过吸收富含脂质的沉积物产生的清晰光声信号证明了该系统检测高速易损动脉粥样硬化斑块的能力。
