Francis Sullibie, Kortei Nii Korley, Sackey Marian, Richard Seidu A
Department of Obstetrics and Gynecology, Ho Teaching Hospital, P.O. Box MA-374, Ho, Ghana.
Department of Nutrition and Dietetics, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Open Med (Wars). 2024 Jan 26;19(1):20240907. doi: 10.1515/med-2024-0907. eCollection 2024.
Aflatoxin B (AFB) is a subsidiary poisonous metabolite, archetypally spawned by and which are often isolated in warm or tropical countries across the world. AFB is capable of disrupting the functioning of several reproductive endocrine glands by interrupting the enzymes and their substrates that are liable for the synthesis of various hormones in both males and females. In men, AFB is capable of hindering testicular development, testicular degeneration, and reduces reproductive capabilities. In women, a direct antagonistic interaction of AFB with steroid hormone receptors influencing gonadal hormone production of estrogen and progesterone was responsible for AFB-associated infertility. AFB is potentially teratogenic and is responsible for the development of malformation in humans and animals. Soft-tissue anomalies such as internal hydrocephalus, microphthalmia, cardiac defects, augmented liver lobes, reproductive changes, immune modifications, behavioral changes and predisposition of animals and humans to neoplasm development are AFB-associated anomalies. Substances such as esculin, selenium, gynandra extract, vitamins C and E, oltipraz, and CDDO-Im are potential therapies for AFB. Thus, this review elucidates the pivotal pathogenic roles of AFB in infertility, fetal deformities, and potential therapies because AFB toxicity is a key problem globally.
黄曲霉毒素B（AFB）是一种次生有毒代谢产物，典型地由黄曲霉和寄生曲霉产生，这两种真菌在世界上许多温暖或热带国家都经常能分离到。AFB能够通过干扰负责男性和女性各种激素合成的酶及其底物，破坏多个生殖内分泌腺的功能。在男性中，AFB能够阻碍睾丸发育、导致睾丸退化，并降低生殖能力。在女性中，AFB与影响雌激素和孕激素性腺激素产生的类固醇激素受体直接发生拮抗相互作用，这是AFB相关不孕症的原因。AFB具有潜在的致畸性，会导致人类和动物出现畸形。诸如内部脑积水、小眼症、心脏缺陷、肝叶增大、生殖变化、免疫改变、行为变化以及动物和人类易患肿瘤等软组织异常都是与AFB相关的异常情况。七叶苷、硒、假败酱提取物、维生素C和E、奥替普拉以及CDDO-Im等物质是治疗AFB的潜在疗法。因此，由于AFB毒性是全球范围内的一个关键问题，本综述阐明了AFB在不孕症、胎儿畸形以及潜在疗法中的关键致病作用。
