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人类食品和动物饲料消费中的 AFB1 毒性:实验处理和预防措施的综述。

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures.

机构信息

Department of Pig Breeding, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland.

Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland.

出版信息

Int J Mol Sci. 2024 May 13;25(10):5305. doi: 10.3390/ijms25105305.

Abstract

AIMS

The current review aims to outline and summarize the latest research on aflatoxin, with research studies describing natural, herbal and chemical compound applications in animal (pig) models and in vitro cellular studies. Aflatoxin, a carcinogenic toxin metabolite, is produced by in humid environments, posing a threat to human health and crop production. The current treatment involves the prevention of exposure to aflatoxin and counteracting its harmful toxic effects, enabling survival and research studies on an antidote for aflatoxin.

OBJECTIVES

To summarize current research prospects and to outline the influence of aflatoxin on animal forage in farm production, food and crop processing. The research application of remedies to treat aflatoxin is undergoing development to pinpoint biochemical pathways responsible for aflatoxin effects transmission and actions of treatment.

SIGNIFICANCE

To underline the environmental stress of aflatoxin on meat and dairy products; to describe clinical syndromes associated with aflatoxicosis on human health that are counteracted with proposed treatment and preventive interventions. To understand how to improve the health of farm animals with feed conditions.

摘要

目的

本综述旨在概述和总结有关黄曲霉毒素的最新研究,研究描述了天然、草药和化学化合物在动物(猪)模型和体外细胞研究中的应用。黄曲霉毒素是一种致癌毒素代谢物,在潮湿的环境中产生,对人类健康和作物生产构成威胁。目前的治疗方法包括预防接触黄曲霉毒素和中和其有害的毒性作用,以实现对黄曲霉毒素解毒剂的生存和研究。

目的

总结目前的研究前景,并概述黄曲霉毒素对农场生产、食品和作物加工中动物饲料的影响。正在开发治疗方法的研究应用,以确定负责黄曲霉毒素作用传递的生化途径和治疗作用。

意义

强调黄曲霉毒素对肉类和奶制品的环境压力;描述与人类黄曲霉毒素中毒相关的临床综合征,并用提出的治疗和预防干预措施加以对抗。了解如何通过饲料条件改善农场动物的健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35c7/11121597/556fa6c0b562/ijms-25-05305-g001.jpg

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