Department of Forest Biomaterials and Technology, Swedish University of Agricultural Sciences, SE- 90183 Umeå, Sweden.
Faculty of Pharmacy, University Grenoble Alpes, Grenoble 38400, France.
Int J Biol Macromol. 2024 Mar;261(Pt 2):129753. doi: 10.1016/j.ijbiomac.2024.129753. Epub 2024 Jan 27.
Lignin's antibacterial properties have become increasingly relevant due to the rise of microbial infectious diseases and antibiotic resistance. Lignin is capable of interacting electrostatically with bacteria and contains polyphenols that cause damage to their cell walls. These features make lignin a desirable material to exhibit antibacterial behavior. Therefore, lignin in antibacterial applications offers a novel approach to address the growing need for sustainable and effective antibacterial materials. Recent research has explored the incorporation of lignin in various biomedical applications, such as wound dressings, implants, and drug delivery systems, highlighting their potential as a sustainable alternative to synthetic antibacterial agents. Furthermore, the development of lignin-based nanomaterials with enhanced antimicrobial activity is an active area of research that holds great promise for the future. In this review, we have provided a summary of how lignin can be incorporated into different forms, such as composite and non-composite synthesis of antibacterial agents and their performances. The challenges and future considerations are also discussed in this review article.
由于微生物传染病和抗生素耐药性的出现，木质素的抗菌性能变得越来越重要。木质素能够与细菌静电相互作用，并含有导致细胞壁受损的多酚。这些特性使木质素成为一种具有抗菌行为的理想材料。因此，在抗菌应用中，木质素提供了一种新颖的方法来满足对可持续和有效抗菌材料的日益增长的需求。最近的研究探讨了将木质素纳入各种生物医学应用中，如伤口敷料、植入物和药物输送系统，强调了其作为合成抗菌剂的可持续替代品的潜力。此外，开发具有增强抗菌活性的基于木质素的纳米材料是一个活跃的研究领域，为未来带来了巨大的希望。在这篇综述中，我们总结了木质素如何被纳入不同的形式，如抗菌剂的复合和非复合合成及其性能。本文还讨论了挑战和未来的考虑因素。
