Gu Yihui, Xu Chao, Wang Yilin, Luo Jing, Shi Dongsheng, Wu Wenjuan, Chen Lu, Jin Yongcan, Jiang Bo, Chen Chaoji
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Hubei Provincial Engineering Research Center of Emerging Functional Coating Materials, School of Resource and Environmental Sciences, Wuhan University, Wuhan, 430079, China.
Nat Commun. 2025 Jan 2;16(1):160. doi: 10.1038/s41467-024-55530-1.
Achieving a synergy of biocompatibility and extreme environmental adaptability with excellent mechanical property remains challenging in the development of synthetic materials. Herein, a "bottom-up" solution-interface-induced self-assembly strategy is adopted to develop a compressible, anti-fatigue, extreme environment adaptable, biocompatible, and recyclable organohydrogel composed of chitosan-lignosulfonate-gelatin by constructing noncovalent bonded conjoined network. The ethylene glycol/water solvent induced lignosulfonate nanoparticles function as bridge in chitosan/gelation network, forming multiple interfacial interactions that can effectively dissipate energy. The organohydrogel exhibits high compressive strength (54 MPa) and toughness (3.54 MJ/m), 100 and 70 times higher than those of pure chitosan/gelatin hydrogel, meanwhile, excellent self-recovery and fatigue resistance properties. Even when subjected to severe compression up to a strain of 0.5 for 500,000 cycles, the organohydrogel still remains intact. This organohydrogel also demonstrates notable biocompatibility both in vivo and vitro, environment adaptability at low temperature, as well as recyclability. Such all natural organohydrogel provides a promising route towards the development of high-performance load-bearing materials.
在合成材料的开发中，实现生物相容性、极端环境适应性与优异机械性能的协同仍然具有挑战性。在此，采用“自下而上”的溶液界面诱导自组装策略，通过构建非共价键连接的联合网络，开发了一种由壳聚糖-木质素磺酸盐-明胶组成的可压缩、抗疲劳、极端环境适应性、生物相容性和可回收的有机水凝胶。乙二醇/水溶剂诱导的木质素磺酸盐纳米颗粒在壳聚糖/凝胶网络中起桥梁作用，形成多种界面相互作用，可有效耗散能量。该有机水凝胶具有高抗压强度（54 MPa）和韧性（3.54 MJ/m），分别比纯壳聚糖/明胶水凝胶高100倍和70倍，同时具有优异的自恢复和抗疲劳性能。即使在高达0.5的应变下进行500,000次循环的剧烈压缩，该有机水凝胶仍保持完整。这种有机水凝胶在体内和体外均表现出显著的生物相容性、低温环境适应性以及可回收性。这种全天然有机水凝胶为高性能承重材料的开发提供了一条有前景的途径。
