Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China.
School of Chemistry and Life Science, Changchun University of Technology, Changchun, China.
Luminescence. 2024 Jan;39(1):e4659. doi: 10.1002/bio.4659.
Specific biomarker-activatable probes have revolutionized theranostics, being beneficial for precision medicine. Hypoxia is a critical pathological characteristic prevalent in numerous major diseases such as cancers, cardiovascular disorders, inflammatory diseases, and acute ischemia. Aggregation-induced emission luminogens (AIEgens) have emerged as a promising tool to tackle the biomedical issues. Of particular significance are the hypoxia-responsive AIEgens, representing a kind of crucial probe capable of delicately sensing and responding to the hypoxic microenvironment, thereby enhancing the precision of disease diagnosis and treatment. In this review, we summarize the recent advances of hypoxia-responsive AIEgens for varied biomedical applications. The hypoxia-responsive structures based on AIEgens, such as azobenzene, nitrobenzene, and N-oxide are presented, which are in response to the reduction property to bring about significant alternations in response spectra and/or fluorescence intensity. The bioapplications including imaging and therapy of tumor and ischemia diseases are discussed. Moreover, the review sheds light on the future challenges and prospects in this field. This review aims to provide comprehensive guidance and understanding into the development of activatable bioprobes, especially the hypoxia-responsive AIEgens for improving the diagnosis and therapy outcome of related diseases.
特异性生物标志物激活探针彻底改变了治疗学，对精准医学有很大的帮助。缺氧是癌症、心血管疾病、炎症性疾病和急性缺血等多种重大疾病中普遍存在的关键病理特征。聚集诱导发光体（AIEgens）已成为解决生物医学问题的一种有前途的工具。特别值得注意的是缺氧反应性 AIEgens，它是一种能够精细感应和响应缺氧微环境的关键探针，从而提高疾病诊断和治疗的精度。在这篇综述中，我们总结了用于各种生物医学应用的缺氧反应性 AIEgens 的最新进展。介绍了基于 AIEgens 的缺氧反应结构，如偶氮苯、硝基苯和 N-氧化物，它们对还原性质做出响应，从而在响应光谱和/或荧光强度上产生显著变化。讨论了包括肿瘤和缺血性疾病的成像和治疗在内的生物应用。此外，该综述还展望了该领域的未来挑战和前景。本综述旨在为可激活生物探针的发展提供全面的指导和理解，特别是缺氧反应性 AIEgens，以改善相关疾病的诊断和治疗效果。
