Scheetz A J, Markham J A, Fifková E
Brain Res. 1987 Feb 10;403(1):151-4. doi: 10.1016/0006-8993(87)90135-1.
The frequency of basket cells in the granule cell layer of the dentate fascia of Short Sleep (SS) and Long Sleep (LS) mice was determined following 3 months of ethanol exposure. These mice were bred for their differential susceptibility to the narcotic effects of acute doses of ethanol. The ethanol-insensitive SS mice were unaffected by the treatment while the ethanol-sensitive LS mice that received ethanol showed a significant decrease in basket cell frequency over their control group counterparts. These basket cells are thought to control the tonic level of activity of the granule cells. Thus, a decrease in basket cell frequency might lead to higher granule cell activity following chronic ethanol exposure. This effect could counteract the assumed stronger depressant effect of ethanol in the relatively ethanol-sensitive LS mice.
在对短期睡眠（SS）和长期睡眠（LS）小鼠进行3个月的乙醇暴露后，测定了齿状筋膜颗粒细胞层中篮状细胞的频率。这些小鼠因其对急性剂量乙醇麻醉作用的不同易感性而培育。乙醇不敏感的SS小鼠不受该处理影响，而接受乙醇处理的乙醇敏感LS小鼠与对照组相比，其篮状细胞频率显著降低。这些篮状细胞被认为可控制颗粒细胞的紧张性活动水平。因此，慢性乙醇暴露后篮状细胞频率降低可能导致颗粒细胞活性升高。这种效应可能抵消了乙醇在相对乙醇敏感的LS小鼠中假定更强的抑制作用。
