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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lang D, Beno M, Fifková E, Eason H

Department of Psychology, University of Colorado, Boulder, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1997 Aug;21(6):1031-42. doi: 10.1016/s0278-5846(97)00096-1.

The effect of ethanol and its withdrawal on the dendritic microtubules in the dentate fascia of male mice was studied in the ethanol-sensitive, long-sleep (LS) line and the ethanol-insensitive, short-sleep (SS) line. 2. Both mouse lines were treated with a liquid ethanol diet. Dendrites in the dentate molecular layer (DML) of the right hippocampus were examined. 3. They revealed marked changes in microtubule density as compared with the controls. While the microtubule density in LS mice was significantly reduced by 15% and 18% in the middle and distal third of the DML, respectively, in SS mice the reduction (by 12%) took place in the distal third only. During withdrawal a recovery of the microtubule density has been observed in both lines.

在对乙醇敏感的长睡眠（LS）品系和对乙醇不敏感的短睡眠（SS）品系雄性小鼠中，研究了乙醇及其戒断对齿状筋膜中树突微管的影响。2. 两个小鼠品系均用液体乙醇饮食处理。检查右侧海马齿状分子层（DML）中的树突。3. 与对照组相比，它们显示出微管密度的显著变化。在LS小鼠中，DML中三分之一和远端三分之一处的微管密度分别显著降低了15%和18%，而在SS小鼠中，仅在远端三分之一处出现了12%的降低。在戒断期间，两个品系均观察到微管密度的恢复。

Lang D, Beno M, Fifková E, Eason H

Department of Psychology, University of Colorado, Boulder, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1997 Aug;21(6):1031-42. doi: 10.1016/s0278-5846(97)00096-1.

The effect of ethanol and its withdrawal on the dendritic microtubules in the dentate fascia of male mice was studied in the ethanol-sensitive, long-sleep (LS) line and the ethanol-insensitive, short-sleep (SS) line. 2. Both mouse lines were treated with a liquid ethanol diet. Dendrites in the dentate molecular layer (DML) of the right hippocampus were examined. 3. They revealed marked changes in microtubule density as compared with the controls. While the microtubule density in LS mice was significantly reduced by 15% and 18% in the middle and distal third of the DML, respectively, in SS mice the reduction (by 12%) took place in the distal third only. During withdrawal a recovery of the microtubule density has been observed in both lines.

在对乙醇敏感的长睡眠（LS）品系和对乙醇不敏感的短睡眠（SS）品系雄性小鼠中，研究了乙醇及其戒断对齿状筋膜中树突微管的影响。2. 两个小鼠品系均用液体乙醇饮食处理。检查右侧海马齿状分子层（DML）中的树突。3. 与对照组相比，它们显示出微管密度的显著变化。在LS小鼠中，DML中三分之一和远端三分之一处的微管密度分别显著降低了15%和18%，而在SS小鼠中，仅在远端三分之一处出现了12%的降低。在戒断期间，两个品系均观察到微管密度的恢复。