State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430079, P. R. China.
Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, P. R. China.
Adv Healthc Mater. 2024 May;13(12):e2304021. doi: 10.1002/adhm.202304021. Epub 2024 Feb 13.
Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease, and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, the advances of biomaterials for ameliorating inflammatory bone loss are listed. Additionally, the advantages and disadvantages of various biomaterials-mediated strategies are summarized. Finally, the challenges and perspectives of biomaterials are analyzed. This review aims to provide new possibilities for developing more advanced biomaterials toward inflammatory bone loss.
炎症性疾病，如类风湿关节炎、牙周炎、慢性阻塞性肺疾病和乳糜泻，会破坏骨吸收和形成之间的微妙平衡，导致炎症性骨丢失。传统的治疗方法包括药物干预和手术。然而，药物干预的疗效有限，而手术治疗会给患者带来创伤和巨大的经济负担。生物材料具有出色的时空可控性、显著的比表面积和卓越的反应性。在当前时代，新兴生物材料的进步为对抗炎症性骨丢失的有害后果提供了更有效的解决方案。在这篇综述中，列出了用于改善炎症性骨丢失的生物材料的进展。此外，还总结了各种基于生物材料的策略的优缺点。最后，分析了生物材料的挑战和展望。本综述旨在为开发更先进的生物材料治疗炎症性骨丢失提供新的可能性。
