Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Department of Pharmaceutics, Faculty of Pharmacy, Elmergib University, Alkhoms, 40414, Libya.
Int J Nanomedicine. 2024 Jan 25;19:825-844. doi: 10.2147/IJN.S447429. eCollection 2024.
Nanosuspensions have garnered recent attention as a promising strategy for mitigating the bioavailability challenges of hydrophobic drugs, particularly those characterized by poor solubility in both aqueous and organic environments. Addressing solubility issues associated with poorly water-soluble drugs has largely resolved the need to enhance drug absorption and bioavailability. As mucosal formulations and topical administration progress in the future, nanosuspension drug delivery, straightforward formulation techniques, and versatile applications will continue to be subjects of interest. Nanosuspensions have undergone extensive scrutiny in preparation for topical applications, encompassing ocular, pulmonary, and dermal usage. Among the numerous methods aimed at improving cutaneous application, nanocrystals represent a relatively recent yet profoundly intriguing approach. Despite the increasing availability of various nanosuspension products, primarily designed for oral administration, only a limited number of studies have explored skin permeability and drug accumulation in the context of nanosuspensions. Nevertheless, the scant published research unequivocally underscores the potential of this approach for enhancing cutaneous bioavailability, particularly for active ingredients with low to medium solubility. Nanocrystals exhibit increased skin adhesiveness in addition to heightened saturation solubility and dissolution rate, thereby augmenting cutaneous distribution. The article provides a comprehensive overview of nanosuspensions for topical application. The methodology employed is robust, with a well-defined experimental design; however, the limited sample size raises concerns about the generalizability of the findings. While the results demonstrate promising outcomes in terms of enhanced drug delivery, the discussion falls short of addressing certain limitations. Additionally, the references largely focus on recent studies, but a more diverse inclusion of historical perspectives could offer a more holistic view of the subject.
纳米混悬剂作为一种有前途的策略，受到了近期的关注，可用于缓解疏水性药物的生物利用度挑战，特别是那些在水相和有机相中的溶解度都较差的药物。解决与水溶性差的药物相关的溶解度问题，在很大程度上解决了提高药物吸收和生物利用度的需求。随着未来黏膜制剂和局部给药的进展，纳米混悬剂药物递送、简单的配方技术和广泛的应用将继续成为关注的主题。纳米混悬剂已经在为局部应用进行了广泛的研究，包括眼部、肺部和皮肤应用。在众多旨在改善皮肤应用的方法中，纳米晶体是一种相对较新但非常有趣的方法。尽管有越来越多的各种纳米混悬剂产品，主要设计用于口服，但只有少数研究探讨了纳米混悬剂在皮肤通透性和药物积累方面的情况。然而，为数不多的已发表研究明确强调了这种方法在提高皮肤生物利用度方面的潜力，特别是对于溶解度低至中等的活性成分。纳米晶体除了提高饱和溶解度和溶解速率外，还表现出增加的皮肤附着力，从而增加皮肤分布。本文全面概述了用于局部应用的纳米混悬剂。所采用的方法是稳健的，具有明确的实验设计；然而，有限的样本量引起了对研究结果的普遍性的担忧。虽然结果表明在增强药物递送方面有有希望的结果，但讨论未能解决某些限制。此外，参考文献主要集中在最近的研究上，但更广泛地包括历史观点可以提供对该主题更全面的看法。
