Liu Jia-Yang, Dai Yu, He Yao-Xi, Lin Lin
School of Elderly Health, Chengdu Medical College, Chengdu, Sichuan, China.
School of Nursing, Chengdu Medical College, Chengdu, Sichuan, China.
Front Pharmacol. 2024 Jan 16;14:1301102. doi: 10.3389/fphar.2023.1301102. eCollection 2023.
Berberine is an isoquinoline alkaloid extracted from Berberis vulgaris, which possesses a variety of pharmacological activities. Alzheimer's disease (AD) is a complex disease with multiple pathologic factors, with cognitive decline being the main manifestation of AD. The neuroprotective effects of berberine in animal models of Alzheimer's disease (AD) have been widely reported, exhibiting protective effects against risk factors associated with AD. In this study, we summarize and evaluate the effects of berberine on cognitive function and β-amyloid precursor protein in animal models of AD. Eligible studies were retrieved from PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Library databases up to 1 June 2023. Risk of bias was assessed by the Systematic Review Center for Laboratory Animal Experiments (SYRCLE). Statistical analyses were performed using STATA 14.0 and Review Manger 5.4 software to calculate weighted standardized mean difference (SMD) and 95% confidence intervals (CI), Morris water maze (MWM) test and β-amyloid precursor protein as outcome measures. Heterogeneity was tested using the I test. Sensitivity analysis and publication bias were also assessed. 19 studies involving 360 animals met the inclusion criteria, and the results of the meta-analysis showed that berberine decreased escape latency (SMD = -2.19, 95% CI: (-2.50, -1.88), < 0.00001), increased the number of platform crossings (SMD = 4.27, 95% CI (3.38, 5.17), < 0.00001), time in the target quadrant (SMD = 5.92, 95% CI (4.43, 7.41), < 0.00001) and APP expression (SMD = 0.73, 95% CI: (0.25, 1.21), = 0.003). Berberine can regulate APP expression and improve cognitive function in animal models of AD, and the mechanism may be related to the involvement of berberine in APP processing and influence the expression of its related factors. PROSPERO, CRD42023437445.
黄连素是从普通小檗中提取的一种异喹啉生物碱，具有多种药理活性。阿尔茨海默病（AD）是一种具有多种病理因素的复杂疾病，认知功能下降是AD的主要表现。黄连素在阿尔茨海默病（AD）动物模型中的神经保护作用已被广泛报道，对与AD相关的危险因素具有保护作用。在本研究中，我们总结并评估了黄连素对AD动物模型认知功能和β-淀粉样前体蛋白的影响。从PubMed、MEDLINE、EMBASE、Web of Science和Cochrane图书馆数据库中检索截至2023年6月1日的符合条件的研究。偏倚风险由实验动物系统评价中心（SYRCLE）评估。使用STATA 14.0和Review Manger 5.4软件进行统计分析，以计算加权标准化平均差（SMD）和95%置信区间（CI），以莫里斯水迷宫（MWM）试验和β-淀粉样前体蛋白作为结局指标。使用I检验检测异质性。还评估了敏感性分析和发表偏倚。19项涉及360只动物的研究符合纳入标准，荟萃分析结果表明，黄连素可缩短逃避潜伏期（SMD = -2.19，95% CI：（-2.50，-1.88），< 0.00001），增加穿越平台次数（SMD = 4.27，95% CI（3.38，5.17），< 0.00001）、在目标象限的时间（SMD = 5.92，95% CI（4.43，7.41），< 0.00001）和APP表达（SMD = 0.73，95% CI：（0.25，1.21），= 0.003）。黄连素可调节AD动物模型中的APP表达并改善认知功能，其机制可能与黄连素参与APP加工并影响其相关因子的表达有关。国际系统评价前瞻性注册库，CRD42023437445。
