Kadyan Pooja, Thillai Arasu Ponnusamy, Kataria Sudhir Kumar
Department of Zoology, Maharshi Dayanand University, Rohtak, Haryana, India.
Department of Chemistry, College of Natural and Computational Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
Int J Biomater. 2024 Jan 23;2024:2626006. doi: 10.1155/2024/2626006. eCollection 2024.
Antibiotic resistance is becoming more common, emphasising the demand for novel antibacterial treatments. The current investigation describes the green synthesis of graphene quantum dots (GQDs) using leaves and characterization via Fourier-transform infrared spectra (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and ultraviolet-visible (UV-Vis) spectrophotometer. The results showed that GQDs are spherical in shape. antioxidant and antimicrobial studies indicate that the biological efficacy of synthesized GQDs was higher than the ethanolic leaf extract. GQDs exhibited the highest scavenging efficacy with lowest IC (half-maximal inhibitory concentration) value. However, antimicrobial study showed more inhibitory activity of GQDs against all screened microorganisms, i.e., , , , and , and fungi, i.e., and . Graphene quantum dots facilitate reactive oxygen species (ROS) which ultimately lead to antioxidant and antibacterial activity. This approach would provide an efficient alternate method for tackling microorganisms.
抗生素耐药性正变得越来越普遍,这凸显了对新型抗菌治疗方法的需求。当前的研究描述了使用树叶进行石墨烯量子点(GQDs)的绿色合成,并通过傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和紫外可见(UV-Vis)分光光度计进行表征。结果表明,石墨烯量子点呈球形。抗氧化和抗菌研究表明,合成的石墨烯量子点的生物学功效高于乙醇叶提取物。石墨烯量子点表现出最高的清除功效,IC(半最大抑制浓度)值最低。然而,抗菌研究表明,石墨烯量子点对所有筛选的微生物,即大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和铜绿假单胞菌,以及真菌,即白色念珠菌和黑曲霉,具有更强的抑制活性。石墨烯量子点促进活性氧(ROS)的产生,最终导致抗氧化和抗菌活性。这种方法将为应对微生物提供一种有效的替代方法。