Heenen M, Achten G, Galand P
Ann Dermatol Venereol. 1979 Feb;106(2):131-9.
Cell kinetic of human epidermis has been studied with different techniques of labeling by 3H-thymidine. A review of the literature for human epidermis, psoriasis and some epidermal tumors has been performed and discussed in the light of our own studies. If the cell cycle time seems to be slightly shorter in epidermal tumors in comparison to normal epidermis, this doesn't constitute the fundamental characteristic of the neoplastic lesions. Indeed the most specific alteration in the cell cycle parameters for precancerous and cancerous tissue is a lengthening of the S phase duration. This modification of the DNA synthesis time is perhaps of reflection of the depressed state of the chromatin of neoplastic tissues.
已采用不同的³H-胸腺嘧啶核苷标记技术对人表皮的细胞动力学进行了研究。根据我们自己的研究，对有关人表皮、银屑病和一些表皮肿瘤的文献进行了综述和讨论。与正常表皮相比，表皮肿瘤中的细胞周期时间似乎略短，但这并非肿瘤性病变的基本特征。实际上，癌前组织和癌组织细胞周期参数中最特异的改变是S期持续时间延长。DNA合成时间的这种改变可能反映了肿瘤组织染色质的抑制状态。
