Dix R D, Streilein J W, Cousins S, Atherton S S
Curr Eye Res. 1987 Jan;6(1):47-52. doi: 10.3109/02713688709020067.
Herpes simplex virus type 1 (HSV-1) inoculated intracamerally into one anterior chamber of a BALB/c mouse produces retinitis in the uninoculated contralateral eye within 7 to 10 days while the retina of the inoculated eye is spared. In sharp contrast, animals receiving HSV type 2 (HSV-2) by the anterior chamber route develop a dramatic retinitis in the inoculated eye by day 7 postinoculation while the retina of the contralateral eye remains uninvolved. Histopathologic examination of retinal destruction in the HSV-2-infected ipsilateral eye revealed features which were distinct from those observed in the contralateral eye of HSV-1-infected animals. Whereas HSV-1 produced a rapid, explosive, retinitis which led to destruction of all cell layers of the contralateral retina, HSV-2 induced a retinitis in the ipsilateral eye that was more gradual in onset. Ipsilateral HSV-2 retinitis was characterized initially by disruption of the ganglion and inner nuclear layers which progressed by day 10 to 14 to complete replacement of the retina by a fibrocellular scar. These changes were dominated by a vigorous mononuclear cell infiltrate, a feature not observed in the HSV-1-infected contralateral retinitis. These results suggest that experimental retinitides produced by HSV-1 and HSV-2 are of diverse pathogenesis.
将1型单纯疱疹病毒（HSV-1）经前房注射到BALB/c小鼠的一个前房内，在7至10天内未接种的对侧眼会发生视网膜炎，而接种眼的视网膜则未受影响。与之形成鲜明对比的是，通过前房途径接种2型单纯疱疹病毒（HSV-2）的动物，在接种后第7天接种眼会出现严重的视网膜炎，而对侧眼的视网膜仍未受累。对HSV-2感染的同侧眼视网膜破坏的组织病理学检查显示，其特征与HSV-1感染动物对侧眼观察到的特征不同。HSV-1会引发快速、爆发性的视网膜炎，导致对侧视网膜所有细胞层遭到破坏，而HSV-2则会在同侧眼诱发视网膜炎，其发病较为缓慢。同侧HSV-2视网膜炎最初的特征是神经节层和内核层遭到破坏，到第10至14天发展为视网膜完全被纤维细胞瘢痕取代。这些变化以强烈的单核细胞浸润为主，这是HSV-1感染的对侧视网膜炎中未观察到的特征。这些结果表明，HSV-1和HSV-2引发的实验性视网膜炎具有不同的发病机制。
