Chen Xiaowan, Hu Kejia, Song Huan, Yin Li, Kaijser Magnus, Gurholt Tiril P, Andreassen Ole A, Valdimarsdóttir Unnur, Fang Fang, Duan Maoli
Department of Otolaryngology Head and Neck Surgery, the First Hospital of Lanzhou University, Lanzhou, Gansu Province, China; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Otolaryngology Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden; and Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
BJPsych Open. 2024 Feb 1;10(2):e37. doi: 10.1192/bjo.2023.634.
Hearing loss and tinnitus have been proposed as potential indicators of impaired mental health and brain morphological changes.
To assess the associations of hearing loss and tinnitus with the risk of depression and anxiety and with brain volume.
We conducted a community-based cohort study including 129 610 participants aged 40-69 years at recruitment to the UK Biobank with a follow-up period during 2006-2021 to estimate the risk of depression and anxiety after detection of hearing loss and reported tinnitus. We also assessed the associations of hearing loss and tinnitus with brain volume in a subsample with available brain magnetic resonance imaging data ( = 5222).
We observed an increased risk of depression among individuals with hearing loss (hazard ratio [HR] 1.14, 95% CI 1.03-1.26), tinnitus (HR 1.30, 95% CI 1.21-1.41) or both (HR 1.32, 95% CI 1.15-1.52), compared with individuals with neither hearing loss nor tinnitus. Similar results were noted for anxiety (HR 1.18, 95% CI 1.07-1.30 for hearing loss; HR 1.32, 95% CI 1.22-1.43 for tinnitus; and HR 1.48, 95% CI 1.30-1.68 for both). Hearing loss was associated with decreased overall brain volume as well as decreased volume of different brain regions. The latter associations disappeared after adjustment for whole intracranial volume. Tinnitus was associated with greater left accumbens and right occipital pole volume after adjustment for the whole intracranial volume.
Individuals with tinnitus are at increased risk of depression and anxiety. Hearing loss, on the other hand, is associated with both mood disorders and altered brain morphology.
听力损失和耳鸣已被提出作为心理健康受损和脑形态学变化的潜在指标。
评估听力损失和耳鸣与抑郁和焦虑风险以及脑容量之间的关联。
我们开展了一项基于社区的队列研究，纳入了英国生物银行招募的129610名年龄在40 - 69岁之间的参与者，随访期为2006年至2021年，以评估在检测到听力损失和报告耳鸣后发生抑郁和焦虑的风险。我们还在一个有可用脑磁共振成像数据的子样本（n = 5222）中评估了听力损失和耳鸣与脑容量之间的关联。
与既无听力损失也无耳鸣的个体相比，我们观察到有听力损失（风险比[HR] 1.14，95%置信区间1.03 - 1.26）、耳鸣（HR 1.30，95%置信区间1.21 - 1.41）或两者皆有的个体患抑郁症的风险增加（HR 1.32，95%置信区间1.15 - 1.52）。焦虑方面也观察到类似结果（听力损失的HR为1.18，95%置信区间1.07 - 1.30；耳鸣的HR为1.32，95%置信区间1.22 - 1.43；两者皆有的HR为1.48，95%置信区间1.30 - 1.68）。听力损失与全脑体积减少以及不同脑区体积减少有关。在调整全颅内体积后，后者的关联消失。在调整全颅内体积后，耳鸣与左侧伏隔核和右侧枕极体积增大有关。
耳鸣个体患抑郁和焦虑的风险增加。另一方面，听力损失与情绪障碍和脑形态改变均有关联。
