Mohammad-Jafari Kave, Naghib Seyed Morteza
Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran.
Curr Med Chem. 2024 Jan 29. doi: 10.2174/0109298673285199231210170549.
Numerous techniques exist for the production of liposomes; however, these methods need to be revised due to their incapacity to achieve precise management of the dimensions and uniformity of liposomes and their inefficient utilization of reagents and resources. One particular challenge lies in replicating accurate form and size control seen in biological cells, as accomplishing this level of precision through macroscale approaches proves exceptionally arduous. The advent of microfluidic technology tackles this problem by lowering liposome synthesis to a centimeter-level chip, drastically cutting related costs, and enhancing liposome manufacturing efficiency and mobility. Although various microfluidic technologies for micro or nanoparticle preparation have been established, manufacturing microfluidic devices poses challenges due to their high cost and time-consuming nature. However, a promising and cost-effective solution lies in additive production, commonly guided by 3D printing. This innovative technique has demonstrated significant potential and has been successfully applied to create microfluidic chips. Here, we will explore using 3D printing to produce microfluidic devices specifically designed for liposome production. Moreover, the biomedical applications of the liposomes produced by 3D printing-fabricated chips will be fully discussed.
存在多种制备脂质体的技术；然而，由于这些方法无法精确控制脂质体的尺寸和均匀性，且试剂和资源利用效率低下，因此需要进行改进。一个特别的挑战在于复制生物细胞中所见的精确形状和尺寸控制，因为通过宏观方法实现这种精确程度被证明极其困难。微流控技术的出现通过将脂质体合成缩小到厘米级芯片来解决这个问题，大幅降低了相关成本，并提高了脂质体的制造效率和灵活性。尽管已经建立了各种用于制备微米或纳米颗粒的微流控技术，但制造微流控设备由于成本高和耗时的性质而面临挑战。然而，一种有前景且具有成本效益的解决方案在于增材制造，通常由3D打印引导。这种创新技术已显示出巨大潜力，并已成功应用于制造微流控芯片。在这里，我们将探索使用3D打印来生产专门设计用于脂质体生产的微流控设备。此外，还将全面讨论由3D打印制造的芯片生产的脂质体的生物医学应用。
