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本文引用的文献

1
Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.用 32-134D 靶向缺氧诱导因子安全有效地治疗小鼠的糖尿病眼病。
J Clin Invest. 2023 Jul 3;133(13):e163290. doi: 10.1172/JCI163290.
2
Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions.细胞间 hif1α 重编程乳腺祖细胞和髓系免疫逃避以驱动高危乳腺病变。
J Clin Invest. 2023 Apr 17;133(8):e164348. doi: 10.1172/JCI164348.
3
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy.HIF 抑制剂 32-134D 与抗 PD-1 治疗联合根除小鼠肝癌。
J Clin Invest. 2022 May 2;132(9). doi: 10.1172/JCI156774.
4
Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.靶向 HIF-1α 可消除肿瘤微环境中 PD-L1 介导的免疫逃逸，但会促进正常组织中的耐受。
J Clin Invest. 2022 May 2;132(9). doi: 10.1172/JCI150846.
5
Hypoxia-inducible factor signaling in pulmonary hypertension.低氧诱导因子信号通路与肺动脉高压
J Clin Invest. 2020 Nov 2;130(11):5638-5651. doi: 10.1172/JCI137558.
6
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer.缺氧诱导因子（HIFs）、血管生成和代谢：乳腺癌中难以捉摸的敌人。
J Clin Invest. 2020 Oct 1;130(10):5074-5087. doi: 10.1172/JCI137552.
7
Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers.遗传性肾癌中的缺氧、血管生成和代谢。
J Clin Invest. 2019 Feb 1;129(2):442-451. doi: 10.1172/JCI120855. Epub 2019 Jan 7.
8
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.HIF-1 介导肿瘤内缺氧和致癌突变的代谢反应。
J Clin Invest. 2013 Sep;123(9):3664-71. doi: 10.1172/JCI67230. Epub 2013 Sep 3.
9
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.腺病毒介导的 HIF-1α 基因转移促进小鼠气道同种异体移植物微血管修复并减轻慢性排斥反应。
J Clin Invest. 2011 Jun;121(6):2336-49. doi: 10.1172/JCI46192. Epub 2011 May 23.
10
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.希佩尔-林道综合征楚瓦什突变促进小鼠肺动脉高压和肺纤维化。
J Clin Invest. 2010 Mar;120(3):827-39. doi: 10.1172/JCI36362. Epub 2010 Feb 8.

Clinical investigation of hypoxia-inducible factors: getting there.

作者信息

Semenza Gregg L

出版信息

J Clin Invest. 2024 Feb 1;134(3):e176253. doi: 10.1172/JCI176253.

DOI:10.1172/JCI176253
PMID:38299596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10836796/
Abstract
摘要