Dymicky M, Huhtanen C N
Antimicrob Agents Chemother. 1979 Jun;15(6):798-801. doi: 10.1128/AAC.15.6.798.
Twelve straight-chain esters, C(5) to C(14), C(16), and C(18), of p-hydroxybenzoic acid were prepared, and their melting points, solubilities in water at 25 degrees C, infrared spectra, dissociation constants (pK(a)), and activities against Clostridium botulinum were determined. These studies also included four commercial straight-chain esters, C(1) to C(4). The most potent activity was exhibited by undecyl and dodecyl esters, which are about 300 times as active as sodium nitrite. Quadratic and cubic equations were developed correlating the activity with pK(a) values and chain length of the esters, respectively.
制备了对羟基苯甲酸的12种直链酯，碳链长度从C(5)到C(14)、C(16)和C(18)，并测定了它们的熔点、25℃时在水中的溶解度、红外光谱、解离常数（pK(a)）以及对肉毒梭菌的活性。这些研究还包括四种市售的直链酯，碳链长度从C(1)到C(4)。十一烷基酯和十二烷基酯表现出最强的活性，其活性约为亚硝酸钠的300倍。分别建立了二次方程和三次方程，将活性与酯的pK(a)值和链长相关联。
