St Clair D M, Blackwood D H, Christie J E
Br J Psychiatry. 1985 Dec;147:702-6. doi: 10.1192/bjp.147.6.702.
The P300 (P3) and other long latency auditory evoked potentials were measured in 15 patients with presenile dementia Alzheimer type (ATD), 16 patients with alcoholic Korsakoff syndrome (KS) and 23 age-matched control subjects. All were drug free for at least four weeks before testing. The latency of the P3 was significantly longer and the amplitude significantly smaller in the ATD group than in both the KS and control groups. The KS group did not differ significantly from the control group in either latency or amplitude of P3 but both the KS and ATD groups had reduced N1 and P2 compared to controls. Using a combination of P3 latency and amplitude, 70% of the ATD patients could be separated from the other groups with no false positives. These findings suggest that evoked potential recording may be of value in the diagnosis of early ATD.
对15例早老性痴呆阿尔茨海默型（ATD）患者、16例酒精性柯萨科夫综合征（KS）患者及23名年龄匹配的对照者测量了P300（P3）及其他长潜伏期听觉诱发电位。所有受试者在测试前至少四周未服用药物。ATD组的P3潜伏期显著延长，波幅显著减小，与KS组和对照组相比均是如此。KS组在P3潜伏期或波幅方面与对照组相比无显著差异，但与对照组相比，KS组和ATD组的N1和P2均降低。采用P3潜伏期和波幅相结合的方法，70%的ATD患者可与其他组区分开来，且无假阳性。这些发现提示诱发电位记录可能对早期ATD的诊断有价值。
