Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1B TL29, District 12, Ho Chi Minh City, Vietnam.
Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam.
Curr Drug Deliv. 2025;22(1):41-62. doi: 10.2174/0115672018275983231207101222.
The biomedical field faces an ongoing challenge in developing more effective anti-cancer medication due to the significant burden that cancer poses on human health. Extensive research has been conducted on the utilization of natural polysaccharides in nanomedicine owing to their properties of biocompatibility, biodegradability, non-immunogenicity, and non-toxicity. These characteristics make them a potent drug delivery system for cancer therapy. The chitosan hyaluronic acid nanoparticle (CSHANp) system, consisting of chitosan and hyaluronic acid nanoparticles, has exhibited considerable potential as a nanocarrier for various cancer drugs, rendering it one of the most auspicious systems presently accessible. The CSHANps demonstrate remarkable drug loading capacity, precise control over drug release, and exceptional selectivity towards cancer cells. These properties enhance the therapeutic effectiveness against cancerous cells. This article aims to provide a comprehensive analysis of CSHANp, focusing on its characteristics, production techniques, applications, and future prospects.
由于癌症对人类健康造成的巨大负担，生物医学领域在开发更有效的抗癌药物方面一直面临着挑战。由于天然多糖具有生物相容性、可生物降解性、无免疫原性和低毒性等特性，因此在纳米医学中对其进行了广泛的研究。这些特性使它们成为癌症治疗的有效药物输送系统。由壳聚糖和透明质酸纳米粒子组成的壳聚糖透明质酸纳米粒子（CSHANp）系统作为各种癌症药物的纳米载体具有很大的潜力，是目前最有前途的系统之一。CSHANps 具有出色的药物负载能力、对药物释放的精确控制以及对癌细胞的出色选择性。这些特性提高了对癌细胞的治疗效果。本文旨在对 CSHANp 进行全面分析，重点介绍其特性、生产技术、应用和未来前景。
