Jiang Yanlin, Cao Yu, Yao Yiqun, Zhang Dianlong, Wang Yuying
Department of Breast and Thyroid Surgery, the Affiliated Zhongshan Hospital of Dalian University, China.
Department of Surgical Oncology and Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
Int J Biol Macromol. 2025 Apr;301:140144. doi: 10.1016/j.ijbiomac.2025.140144. Epub 2025 Jan 21.
The pervasive global health concern of breast cancer necessitates the development of innovative therapeutic interventions to enhance efficacy and mitigate adverse effects. Chitosan and hyaluronic acid, recognized for their biocompatibility and biodegradability, present compelling options for the novel drug delivery systems and therapeutic platforms in the context of breast cancer management. This review will delineate the distinctive attributes of chitosan and hyaluronic acid, encompassing their inherent anticancer properties, targeting capabilities, and suitability for chemical modifications along with nanoparticle development. These characteristics render them exceptionally well-suited for the fabrication of nanoparticles and hydrogels. The intrinsic anticancer potential of chitosan, in conjunction with its mucoadhesive properties, and the robust binding affinity of hyaluronic acid to CD44 receptors, facilitate specific drug delivery to the malignant cells, thus circumventing the limitations inherent in traditional treatment modalities such as chemotherapy. The incorporation of these materials into nanocarriers allows for the co-delivery of therapeutic agents, thereby potentiating synergistic effects, while hydrogel systems provide localized, controlled drug release and facilitate tissue regeneration. An analysis of advancements in their synthesis, functionalization, and application is presented, while also acknowledging challenges pertaining to scalability and clinical translation.
乳腺癌作为一种普遍存在的全球健康问题，需要开发创新的治疗干预措施，以提高疗效并减轻不良反应。壳聚糖和透明质酸因其生物相容性和可生物降解性而闻名，在乳腺癌管理方面，它们为新型药物递送系统和治疗平台提供了极具吸引力的选择。本综述将阐述壳聚糖和透明质酸的独特属性，包括它们固有的抗癌特性、靶向能力，以及在化学修饰和纳米颗粒开发方面的适用性。这些特性使它们非常适合用于制造纳米颗粒和水凝胶。壳聚糖固有的抗癌潜力及其粘膜粘附特性，以及透明质酸与CD44受体的强大结合亲和力，有助于将药物特异性递送至恶性细胞，从而规避传统治疗方式（如化疗）固有的局限性。将这些材料纳入纳米载体可实现治疗剂的共递送，从而增强协同效应，而水凝胶系统则可实现局部、可控的药物释放，并促进组织再生。本文分析了它们在合成、功能化和应用方面的进展，同时也认识到与可扩展性和临床转化相关的挑战。
