Department of Chemical and Materials Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky 40506, USA.
J Biomed Mater Res A. 2009 Dec;91(3):903-9. doi: 10.1002/jbm.a.32322.
With the growing interest in nanocomposites and their applications in biology and medicine, studies examining the biocompatibility of those materials are critical. Magnetic hydrogel nanocomposites based on poly(N-isopropylacrylamide) and iron oxide nanoparticles were fabricated via UV-polymerization with tetra(ethylene glycol) dimethacrylate acting as the crosslinking agent. In vitro biocompatibility analysis via NIH 3T3 murine fibroblast cytotoxicity was investigated. The fibroblasts in both direct and indirect contact with the hydrogels exhibited favorable cell viability indicating minimal cytotoxicity of the systems. In addition, swelling studies indicated that hydrogels with lower crosslink densities yield higher swelling ratios and that the presence of magnetic nanoparticle did not affect the swelling response of the hydrogel systems. Upon exposure to an alternating magnetic field, the hydrogel nanocomposites with iron oxide nanoparticles showed the capability for remote heating. This evaluation shows that these hydrogels have the potential to be used in biomedical applications such as drug delivery and hyperthermia for cancer treatment.
随着人们对纳米复合材料及其在生物学和医学中应用的兴趣日益浓厚，研究这些材料的生物相容性至关重要。本研究通过紫外光聚合制备了基于聚（N-异丙基丙烯酰胺）和氧化铁纳米粒子的磁性水凝胶纳米复合材料，四甘醇二甲基丙烯酸酯作为交联剂。通过 NIH 3T3 鼠成纤维细胞细胞毒性的体外生物相容性分析发现，直接和间接接触水凝胶的成纤维细胞均表现出良好的细胞活力，表明该体系的细胞毒性极小。此外，溶胀研究表明，交联密度较低的水凝胶具有更高的溶胀比，并且磁性纳米粒子的存在并不影响水凝胶体系的溶胀响应。在交变磁场的作用下，含有氧化铁纳米粒子的水凝胶纳米复合材料具有远程加热的能力。该评估表明，这些水凝胶有可能用于生物医学应用，如药物输送和癌症治疗的热疗。
