Novianti Yessy, Nur'aeny Nanan
Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
J Inflamm Res. 2024 Jan 31;17:541-552. doi: 10.2147/JIR.S449546. eCollection 2024.
Interleukin-10 (IL-10) is a cytokine that plays an important role in the progression of diabetes mellitus (DM). Oral diseases were more common in diabetics than in non-diabetics. The aim of this review is to identify IL-10 levels in diabetic patients with and without oral diseases.
A systematic review was conducted based on the PRISMA guidelines. Three databases (PubMed, Cochrane Library, and Science Direct) were used to search for articles up to November 2023 for studies on the measurement of IL-10 in diabetics with and without oral disease. The criteria were limited to human studies and full-text in English only. The outcome was the value of IL-10. The study was quality-graded using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS).
There were eleven articles that met the eligibility criteria for analysis. Four articles discovered higher IL-10 levels, while seven articles discovered lower IL-10 levels in diabetes patients with oral diseases compared with each control group.
Most studies showed lower IL-10 levels in diabetic patients with oral diseases compared with the control group.
白细胞介素-10（IL-10）是一种在糖尿病（DM）进展中起重要作用的细胞因子。口腔疾病在糖尿病患者中比非糖尿病患者更常见。本综述的目的是确定患有和未患有口腔疾病的糖尿病患者的IL-10水平。
根据PRISMA指南进行系统综述。使用三个数据库（PubMed、Cochrane图书馆和科学Direct）检索截至2023年11月的关于测量患有和未患有口腔疾病的糖尿病患者IL-10的研究文章。标准仅限于人体研究且仅限英文全文。结果是IL-10的值。使用非随机研究的偏倚风险评估工具（RoBANS）对研究进行质量分级。
有11篇文章符合分析的纳入标准。与每个对照组相比，4篇文章发现糖尿病合并口腔疾病患者的IL-10水平较高，而7篇文章发现其IL-10水平较低。
大多数研究表明，与对照组相比，患有口腔疾病的糖尿病患者的IL-10水平较低。
