白细胞介素-35 在牙周病中的病理生物学：系统范围综述。

Interleukin-35 pathobiology in periodontal disease: a systematic scoping review.

机构信息

Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032, Zurich, Switzerland.

Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

BMC Oral Health. 2021 Mar 20;21(1):139. doi: 10.1186/s12903-021-01515-1.

DOI:10.1186/s12903-021-01515-1

PMID:33743678

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7981974/

Abstract

BACKGROUND

Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 mediates immunological functions and plays a protective role in several diseases such as asthma and rheumatoid arthritis. However, the role of IL-35 in gingivitis and periodontitis remains unclear. The aim of this study was to systematically review the literature and collecting the available evidence regarding the role of IL-35 in pathogenesis of periodontal disease.

METHODS

A systematic search of electronic databases including MEDLINE, Google Scholar, Cochrane Library, Web of Science, and Scopus was conducted in November 2020 to identify studies addressing the Interleukin-35 pathobiology in periodontal disease. The identified studies were subjected to pre-identified inclusion criteria. The retrived papers were assessed by the authours independently and consensus was reached in cases where disagreement occurred. Articles written in languages other than English, case reports, letters to editors, conference abstracts, theses, and dissertations were excluded from the review.

RESULTS

A total of 176 possibly relevant articles were identified through the search strategy. Finally, 15 papers which met the criteria of eligibility were included in this review by consensus. The included articles were classified based on their design and level of evidence.Three subclinical study, ten cross sectional investigation and two randomized clinical trials constituted the final set of studies in this review. At preclinical level, Il-35 showed inhibitory characteristics regarding alveolar bone resorption of animal periodontitis models. The results of observatory human studies confirmed the presence of high levels of IL-35 in saliva, GCF, serum, and gingival biopsies of patients suffering from inflammatory periodontal disease. Moreover, two included clinical trials showed that non-surgical periodontal therapy could downregulate IL-35 production in chronic periodontitis patients.

CONCLUSION

Interleukin-35 has an undeniable role in pathobiology of inflammatory periodontal disease. Further well-controlled studies are needed to better elucidate the functional pattern of IL-35 in pathogeneisis of gingival and periodontal disease.

摘要

背景

白细胞介素（IL）-35 是一种新型抗炎细胞因子，由调节性 T 细胞产生。IL-35 介导免疫功能，并在哮喘和类风湿关节炎等几种疾病中发挥保护作用。然而，IL-35 在牙龈炎和牙周炎中的作用尚不清楚。本研究旨在系统回顾文献，并收集关于 IL-35 在牙周病发病机制中的作用的现有证据。

方法

2020 年 11 月，我们对 MEDLINE、Google Scholar、Cochrane 图书馆、Web of Science 和 Scopus 等电子数据库进行了系统检索，以确定研究白细胞介素-35 在牙周病发病机制中的作用的研究。确定的研究符合预先确定的纳入标准。作者独立评估检索到的论文，如果存在分歧，则达成共识。从综述中排除了用其他语言书写的文章、病例报告、给编辑的信件、会议摘要、论文和学位论文。

结果

通过搜索策略共确定了 176 篇可能相关的文章。最终，通过共识，有 15 篇符合入选标准的论文被纳入本综述。根据设计和证据水平对纳入的文章进行分类。三篇亚临床研究、十项横断面研究和两项随机临床试验构成了本综述的最终研究集。在临床前水平，IL-35 对动物牙周炎模型的牙槽骨吸收表现出抑制特征。观察性人类研究的结果证实，患有炎症性牙周病的患者的唾液、龈沟液、血清和牙龈组织活检中存在高水平的 IL-35。此外，两项纳入的临床试验表明，非手术牙周治疗可以下调慢性牙周炎患者的 IL-35 产生。