Left bundle branch pacing biventricular pacing in heart failure patients with left bundle branch block: A systematic review and meta-analysis.

BACKGROUND

Left bundle branch pacing (LBBP) is a novel pacing modality of cardiac resynchronization therapy (CRT) that achieves more physiologic native ventricular activation than biventricular pacing (BiVP).

AIM

To explore the validity of electromechanical resynchronization, clinical and echocardiographic response of LBBP-CRT.

METHODS

Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology section.

RESULTS

In our analysis, the success rate of LBBP-CRT was determined to be 91.1%. LBBP-CRT significantly shortened QRS duration, with significant improvement in echocardiographic parameters, including left ventricular ejection fraction, left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with BiVP-CRT.

CONCLUSION

A significant reduction in New York Heart Association class and B-type natriuretic peptide levels was also observed in the LBBP-CRT group BiVP-CRT group. Lastly, the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.