Tahir M, Fakhar-E-Alam M, Asif Muhammad, Iqbal M Javaid, Abbas Aoun, Hassan Mudassir, Rehman Javed, Bhatti Qaisar Abbas, Mustafa Ghulam, Alothman Asma A, Mohammad Saikh
Department of Physics, Government College University, Faisalabad, 38000, Pakistan.
Department of Zoology, Government College University, Faisalabad, 38000, Pakistan.
Heliyon. 2024 Jan 19;10(3):e24792. doi: 10.1016/j.heliyon.2024.e24792. eCollection 2024 Feb 15.
Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI).
磁性尖晶石铁氧体纳米颗粒（MSF-NPs）是生物医学应用的潜在候选材料，特别是由于其优异的物理化学和磁性特性，在癌症诊断和治疗方面。在当前研究中，通过溶胶-凝胶自燃法制备了MSF-NPs。通过X射线衍射（XRD）和扫描电子显微镜（SEM）确认了晶体结构和表面形态。通过振动样品磁强计（VSM）研究了磁性特性。随着钆浓度的增加，室温下饱和磁化强度值从（17.8 - 2.3）emu/g降低，矫顽力从（499 - 133）奥斯特降低。最后，通过MTT法测试了制备的MSF-NPs的抗癌活性。观察到IC = 21.27μg/mL的值，表明这些纳米颗粒具有很强的抗增殖活性。这些结果表明，由于其优异的磁性特性，所获得的MSF-NPs将可用于癌症治疗的远程控制热疗和磁共振成像（MRI）应用。这些独特的特性使MSF-NPs最适合用于癌症治疗和明亮的造影剂（T1-MRI）。
