Uncertain SEIAR system dynamics modeling for improved community health management of respiratory virus diseases: A COVID-19 case study.

The study investigates the significance of employing advanced systemic models in community health management, with a focus on COVID-19 as a respiratory virus. Through the development of a system dynamics model integrating an uncertain SEIAR model, our research addresses the critical issue of parameter uncertainty using Ensemble Kalman Filter (EnKF) and Metropolis-Hastings (MH) algorithms. We present a case study using real COVID-19 outbreaks in Iran, offering insights into effective outbreak control scenarios and considering the global impact of respiratory viruses. The research yields distinctive results, showcasing variable mortality rates (40,500 to 436,500) across scenarios in Iran. Model accuracy is rigorously evaluated using the Normalized Root-Mean-Square Deviation (NRMSD) for new cases, deaths, and recoveries (0.2 %, 1.2 %, and 0.6 % respectively). The outcomes not only contribute to the existing body of knowledge but also offer practical implications for healthcare policies, economic considerations, and sensitivity assessments related to respiratory diseases. This study stands out from others in its approach to modeling and addressing uncertainty within a system dynamics framework. The integration of EnKF and MH algorithms provides a nuanced understanding of parameter uncertainty, adding a layer of sophistication to the analysis. The application of the model to real-world COVID-19 outbreaks in Iran further enhances the study's relevance and applicability. In conclusion, the research introduces an uncertain SEIAR system dynamics model with unique contributions to policymaking, economic considerations, and sensitivity assessments for respiratory diseases. The outcomes and insights derived from the study not only advance our understanding of disease dynamics but also provide actionable information for effective public health management.