Effectiveness analysis of multiple epidemic prevention measures in the context of COVID-19 using the SVIRD model and ensemble Kalman filter.

The ability to accurately forecast the spread of coronavirus disease 2019 (COVID-19) is of great importance to the resumption of societal normality. Existing methods of epidemic forecasting often ignore the comprehensive analysis of multiple epidemic prevention measures. This paper aims to analyze various epidemic prevention measures through a compound framework. Here, a susceptible-vaccinated-infected-recovered-deceased (SVIRD) model is constructed to consider the effects of population mobility among origin and destination, vaccination, and positive retest populations. And we further use real-time observations to correct the model trajectory with the help of data assimilation. Seven prevention measures are used to analyze the short-term trend of active cases. The results of the synthetic scene recommended that four measures-improving the vaccination protection rate (IVPR), reducing the number of contacts per person per day (RNCP), selecting the region with less infected people as origin A (SES-O) and limiting population flow entering from A to B per day (LAIP-OD)-are the most effective in the short-term, with maximum reductions of 75%, 53%, 35% and 31%, respectively, in active cases after 150 days. The results of the real-world experiment with Hong Kong as the origin and Shenzhen as the destination indicate that when the daily vaccination rate increased from 5% to 9.5%, the number of active cases decreased by only 7.35%. The results demonstrate that reducing the number of contacts per person per day after productive life resumes is more effective than increasing vaccination rates.