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乳腺血管肉瘤:综述

Angiosarcoma of the breast: A review.

作者信息

An Ran, Men Xiao-Juan, Ni Xi-Hao, Wang Wei-Tao, Wang Chang-Liang

机构信息

School of Clinical Medicine, Shandong Second Medical University, Weifang 261041, Shandong Province, China.

Department of Thyroid and Breast Surgery, Weifang People's Hospital, Weifang 261041, Shandong Province, China.

出版信息

Heliyon. 2024 Jan 19;10(3):e24413. doi: 10.1016/j.heliyon.2024.e24413. eCollection 2024 Feb 15.

DOI:10.1016/j.heliyon.2024.e24413
PMID:38318005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10839862/
Abstract

Breast angiosarcoma is a rare and highly aggressive malignancy with a poor prognosis. It can occur spontaneously or be associated with factors such as radiation therapy or chronic lymphedema. The etiology and pathogenesis of this disease are still unclear, the clinical symptoms and imaging findings lack specificity, and the pathological morphology is diverse, which is easy to be confused with other diseases. There is no clear guideline for surgical treatment. Although the optimal surgical approach remains unclear, the ultimate goal is surgical excision with optimal margins, which remains the primary method of treatment. In clinical practice, the choice of the surgical approach should be made by considering the tumor size, pathological type, and patient preferences. In clinical practice, the selection of surgical methods should be carried out with comprehensive consideration of tumor size, pathological types and patients' wishes. There is no clear consensus on whether radiotherapy and chemotherapy should be carried out after surgery, and its optimal program and efficacy are uncertain. This article reviews the etiology, clinical manifestations, pathological features, imaging findings, treatment, prognosis and other aspects of breast angiosarcoma, so as to strengthen clinicians' overall understanding of this disease and avoid missed diagnosis and misdiagnosis.

摘要

乳腺血管肉瘤是一种罕见且侵袭性很强的恶性肿瘤,预后较差。它可自发发生,或与放疗、慢性淋巴水肿等因素有关。该病的病因和发病机制尚不清楚,临床症状和影像学表现缺乏特异性,病理形态多样,容易与其他疾病混淆。目前尚无明确的手术治疗指南。虽然最佳手术方式仍不明确,但最终目标是进行切缘阴性的手术切除,这仍是主要的治疗方法。在临床实践中,手术方式的选择应综合考虑肿瘤大小、病理类型和患者意愿。对于术后是否应进行放疗和化疗,目前尚无明确共识,其最佳方案和疗效也不确定。本文对乳腺血管肉瘤的病因、临床表现、病理特征、影像学表现、治疗、预后等方面进行综述,以增强临床医生对该病的全面认识,避免漏诊和误诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d2/10839862/3ccf7d3fa07e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d2/10839862/3ccf7d3fa07e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d2/10839862/3ccf7d3fa07e/gr1.jpg

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本文引用的文献

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Angiosarcoma of the Breast: Overview of Current Data and Multimodal Imaging Findings.乳腺血管肉瘤:当前数据概述及多模态影像学表现
J Imaging. 2023 Apr 30;9(5):94. doi: 10.3390/jimaging9050094.
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Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast.乳腺血管肉瘤的临床病理特征和生存结局。
Cancer Med. 2023 Jun;12(12):13397-13407. doi: 10.1002/cam4.6042. Epub 2023 May 4.
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Angiosarcoma of the breast with hypofibrinogenemia: A rare case report and review of the literature.伴有低纤维蛋白原血症的乳腺血管肉瘤:1例罕见病例报告及文献复习
严重多发伤救治过程中意外发现小肠血管肉瘤:一例报告
Cureus. 2025 Feb 19;17(2):e79324. doi: 10.7759/cureus.79324. eCollection 2025 Feb.
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Nomogram construction for overall survival in breast angiosarcoma based on clinicopathological features: a population-based cohort study.基于临床病理特征构建乳腺血管肉瘤总生存列线图:一项基于人群的队列研究
Discov Oncol. 2025 Mar 18;16(1):351. doi: 10.1007/s12672-025-02118-w.
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Neoadjuvant chemotherapy for radiation associated angiosarcoma (RAAS) of the breast: A retrospective single center study.新辅助化疗治疗放射相关血管肉瘤(RAAS):回顾性单中心研究。
Breast. 2024 Dec;78:103825. doi: 10.1016/j.breast.2024.103825. Epub 2024 Oct 21.
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Genomic landscape and preclinical models of angiosarcoma.血管肉瘤的基因组图谱与临床前模型
Mol Oncol. 2025 Apr;19(4):965-983. doi: 10.1002/1878-0261.13744. Epub 2024 Oct 5.
Front Oncol. 2022 Nov 2;12:1047935. doi: 10.3389/fonc.2022.1047935. eCollection 2022.
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Histopathologic Grading Is of Prognostic Significance in Primary Angiosarcoma of Breast: Proposal of a Simplified 2-tier Grading System.乳腺原发性血管肉瘤的组织病理学分级具有预后意义:建议简化的 2 级分级系统。
Am J Surg Pathol. 2023 Mar 1;47(3):307-317. doi: 10.1097/PAS.0000000000001998. Epub 2022 Nov 15.
5
Radiation therapy and antiangiogenic therapy: Opportunities and challenges.放射治疗与抗血管生成治疗:机遇与挑战。
Cancer Radiother. 2022 Oct;26(6-7):962-967. doi: 10.1016/j.canrad.2022.06.012. Epub 2022 Aug 18.
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Angiosarcoma of the breast, the unknown-a review of the current literature.乳腺血管肉瘤:未知领域——当前文献综述
Transl Cancer Res. 2019 Oct;8(Suppl 5):S510-S517. doi: 10.21037/tcr.2019.07.38.
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