CSO Department, Cellworks Research India Pvt Ltd, Bengaluru 560066, Karnataka, India.
Department of Biotechnology, Chandigarh University, Punjab 140413, India.
ACS Infect Dis. 2024 Mar 8;10(3):827-844. doi: 10.1021/acsinfecdis.3c00649. Epub 2024 Feb 6.
Malaria, a life-threatening infectious disease caused by , remains a significant global health challenge, particularly in tropical and subtropical regions. The epidemiological data for 2021 revealed a staggering toll, with 247 million reported cases and 619,000 fatalities attributed to the disease. This formidable global health challenge continues to perplex researchers seeking a comprehensive understanding of its pathogenesis. Recent investigations have unveiled the pivotal role of extracellular vesicles (EVs) in this intricate landscape. These tiny, membrane-bound vesicles, secreted by diverse cells, emerge as pivotal communicators in malaria's pathogenic orchestra. This Review delves into the multifaceted roles of EVs in malaria pathogenesis, elucidating their impact on disease progression and immune modulation. Insights into EV involvement offer potential therapeutic and diagnostic strategies. Integrating this information identifies targets to mitigate malaria's global impact. Moreover, this Review explores the potential of EVs as diagnostic biomarkers and therapeutic targets in malaria. By deciphering the intricate dialogue facilitated by these vesicles, new avenues for intervention and novel strategies for disease management may emerge.
疟疾是一种由疟原虫引起的危及生命的传染病，仍然是一个重大的全球健康挑战，特别是在热带和亚热带地区。2021 年的流行病学数据显示，疟疾造成了惊人的损失，报告病例 2.47 亿例，死亡 61.9 万人。这一严峻的全球健康挑战继续困扰着研究人员，他们试图全面了解其发病机制。最近的研究揭示了细胞外囊泡（EVs）在这一复杂景观中的关键作用。这些微小的、膜结合的囊泡由各种细胞分泌，是疟疾发病机制中至关重要的交流者。这篇综述深入探讨了 EVs 在疟疾发病机制中的多方面作用，阐明了它们对疾病进展和免疫调节的影响。对 EV 参与的深入了解为治疗和诊断策略提供了潜力。整合这些信息确定了减轻疟疾全球影响的目标。此外，本综述探讨了 EVs 在疟疾作为诊断生物标志物和治疗靶点的潜力。通过破译这些囊泡介导的复杂对话，可能会出现新的干预途径和疾病管理的新策略。
