BioSystems Laboratory, Department of Earth and Environment Physics, Federal University of Bahia, Salvador, Brazil.
BioSystems Laboratory, Department of Earth and Environment Physics, Federal University of Bahia, Salvador, Brazil.
Comput Biol Med. 2024 Mar;170:108053. doi: 10.1016/j.compbiomed.2024.108053. Epub 2024 Jan 28.
Magnetic fluid hyperthermia (MFH) is a technique whose results show promise in the treatment against cancer, but which still faces obstacles such as controlling the spatial distribution of temperature. The present study developed an agent-based model in order to simulate the temperature changes in an aqueous environment submitted to the magnetic fluid hyperthermia technique. The developed model was built with its parameters based on the clinical treatment protocol for glioblastoma multiforme (GBM). Using thermodynamic properties of magnetic fluid and tissues, we define a specific thermal parameter (α) and evaluate its influence, together with the intensity of the external magnetic field (H), on the dynamics of the temperature of the cancer environment. The temperature evolution generated by the model was in accordance with experimental results known from the subject literature. The parameters evaluation indicates that the temperature stabilization of the tumor environment during MFH treatment is due to the local interactions of energy diffusion, as well as indicating that the α-parameter is a key factor for controlling the temperature and heating speed.
磁流体热疗（MFH）是一种在癌症治疗方面显示出前景的技术，但仍面临着诸如控制温度空间分布等障碍。本研究开发了一种基于代理的模型，以便模拟水基环境中磁流体热疗技术引起的温度变化。所开发的模型的参数是基于多形性胶质母细胞瘤（GBM）的临床治疗方案确定的。利用磁流体和组织的热力学性质，我们定义了一个特定的热参数（α），并评估了它与外加磁场强度（H）一起对癌症环境温度动态的影响。模型生成的温度演化与该主题文献中已知的实验结果一致。参数评估表明，MFH 治疗期间肿瘤环境温度的稳定是由于能量扩散的局部相互作用所致，并且表明α参数是控制温度和加热速度的关键因素。
