磁场热疗中球形组织内温度分布的晶格玻尔兹曼方法数值研究。

Numerical study of temperature distribution in a spherical tissue in magnetic fluid hyperthermia using lattice Boltzmann method.

机构信息

Mechanical Engineering Department, KurdistanUniversity, Sanandaj, Iran.

出版信息

IEEE Trans Nanobioscience. 2011 Dec;10(4):262-8. doi: 10.1109/TNB.2011.2177100.

DOI:10.1109/TNB.2011.2177100

Abstract

This work applies a three-dimensional lattice Boltzmann method (LBM), to solve the Pennes bio-heat equation (BHE), in order to predict the temperature distribution in a spherical tissue, with blood perfusion, metabolism and magnetic nanoparticles (MNPs) heat sources, during magnetic fluid hyperthermia (MFH). So, heat dissipation of MNPs under an alternating magnetic field has been studied and effect of different factors such as induction and frequency of magnetic field and volume fraction of MNPs has been investigated. Then, effect of MNPs dispersion on temperature distribution inside tumor and its surrounding healthy tissue has been shown. Also, effect of blood perfusion, thermal conductivity of tumor, frequency and amplitude of magnetic field on temperature distribution has been explained. Results show that the LBM has a good accuracy to solve the bio-heat transfer problems.

摘要

这项工作应用了三维晶格玻尔兹曼方法（LBM），以求解 Pennes 生物传热方程（BHE），以便在磁流体热疗（MFH）期间预测具有血液灌注、代谢和磁性纳米颗粒（MNPs）热源的球形组织中的温度分布。因此，研究了 MNPs 在交变磁场下的散热，研究了不同因素的影响，如磁场的感应和频率以及 MNPs 的体积分数。然后，展示了 MNPs 分散对肿瘤内部和周围健康组织内温度分布的影响。还解释了血液灌注、肿瘤热导率、磁场频率和幅度对温度分布的影响。结果表明，LBM 具有很好的准确性来解决生物传热问题。