Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Respir Res. 2024 Feb 8;25(1):84. doi: 10.1186/s12931-024-02719-z.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease and a major health burden worldwide. Extracellular vesicles (EVs) are nanosized vesicles which possess a lipid bilayer structure that are secreted by various cells. They contain a variety of bioactive substances, which can regulate various physiological and pathological processes and are closely related to the development of diseases. Recently, EVs have emerged as a novel tool for intercellular crosstalk, which plays an essential role in COPD development. This paper reviews the role of EVs in the development of COPD and their potential clinical value, in order to provide a reference for further research on COPD.
慢性阻塞性肺疾病（COPD）是一种异质性肺部疾病，也是全球范围内的主要健康负担。细胞外囊泡（EVs）是一种纳米大小的囊泡，具有脂质双层结构，由各种细胞分泌。它们包含多种生物活性物质，可以调节各种生理和病理过程，与疾病的发展密切相关。最近，EVs 作为细胞间通讯的新工具出现，在 COPD 的发展中起着至关重要的作用。本文综述了 EVs 在 COPD 发病机制中的作用及其潜在的临床价值，以期为 COPD 的进一步研究提供参考。
