Xie Jing-Yi, Ju Jie, Zhou Ping, Chen Hao, Wang Shao-Cong, Wang Kai, Wang Tao, Chen Xin-Zhe, Chen Yan-Chun, Wang Kun
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, 266021, China.
Department of Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, China.
Cell Death Discov. 2024 Feb 8;10(1):66. doi: 10.1038/s41420-024-01830-w.
Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene expression, cell development, and disease treatment. In the past over ten years, numerous signs of progress have been made in the research on the biochemistry of Kcr modification, especially a series of Kcr modification-related "reader", "eraser", and "writer" enzyme systems are identified. The physiological function of crotonylation and its correlation with development, heredity, and spermatogenesis have been paid more and more attention. However, the development of disease is usually associated with abnormal Kcr modification. In this review, we summarized the identification of crotonylation modification, Kcr-related enzyme system, biological functions, and diseases caused by abnormal Kcr. This knowledge supplies a theoretical basis for further exploring the function of crotonylation in the future.
组蛋白赖氨酸巴豆酰化（Kcr）是2011年首次发现的一种新型酰化修饰，对基因表达、细胞发育和疾病治疗具有重要的生物学意义。在过去十多年里，Kcr修饰的生物化学研究取得了许多进展迹象，尤其是鉴定出了一系列与Kcr修饰相关的“读取器”“擦除器”和“写入器”酶系统。巴豆酰化的生理功能及其与发育、遗传和精子发生的相关性越来越受到关注。然而，疾病的发生通常与Kcr修饰异常有关。在本综述中，我们总结了巴豆酰化修饰的鉴定、与Kcr相关的酶系统、生物学功能以及由Kcr异常引起的疾病。这些知识为未来进一步探索巴豆酰化的功能提供了理论基础。
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