Florida Institute for Reproductive Medicine, 836 Prudential Dr, Suite 902, Jacksonville, FL, 32207, USA.
University of California, San Francisco, 499 Illinois St, San Francisco, CA, 94158, USA.
J Assist Reprod Genet. 2024 Apr;41(4):1077-1085. doi: 10.1007/s10815-023-03013-5. Epub 2024 Feb 9.
This study aimed to (1) determine differences in depression, anxiety, body image, quality-of-life (QOL), and decision regret scale (DRS) scores in transgender individuals undergoing fertility preservation (FP) compared to those who decline and (2) determine if DRS score following FP varies between transgender individuals and cisgender women.
Sixteen transgender birth-assigned (BA) females and 13 BA males, undergoing FP consultation at an academic center between January 2016 and November 2019, were compared to each other and cisgender cohorts with pre-existing data: 201 women undergoing elective oocyte cryopreservation (EOC) between 2012 and 2016 and 44 women with cancer undergoing FP between 1993 and 2007. Outcomes included demographics; validated scales for depression, anxiety, body image, QOL (see below) in the trans cohort; DRS score in all three cohorts.
Of 29 transgender individuals participating, 10 BA females (62%) and 12 BA males (92%) underwent FP. Beck Depression Inventory II, Hospital Anxiety and Depression Scale, Body Image Scale for Transsexuals, Satisfaction with Life Scale, Short Form Health Survey-36, and DRS scores were not significantly different between trans individuals who underwent FP and those who declined. On univariate modeling, regret was significantly lower in transpeople undergoing FP compared to those who did not (OR 0.118, p = 0.03). BA female and BA male transpatients undergoing FP reported DRS median scores 5 (mean 9) and 7.5 (mean 15), respectively, both were not significantly different from cisgender women (p = 0.97, p = 0.25) nor from each other (p = 0.43).
Depression, anxiety, body image, and QOL, in a group of individuals presenting for FP consultation, appear similar between transpeople undergoing FP and not, while regret is significantly lower in those choosing FP. FP is an option for transgender individuals without significant differences in regret compared to cisgender women.
本研究旨在：（1）比较接受生育力保存（FP）的跨性别个体与拒绝接受 FP 的个体之间在抑郁、焦虑、身体意象、生活质量（QOL）和决策后悔量表（DRS）评分方面的差异；（2）确定 FP 后 DRS 评分是否在跨性别个体和 cisgender 女性之间存在差异。
将 2016 年 1 月至 2019 年 11 月在学术中心接受 FP 咨询的 16 名跨性别出生分配（BA）女性和 13 名 BA 男性与具有预存数据的 cisgender 队列进行比较：2012 年至 2016 年期间接受选择性卵母细胞冷冻保存（EOC）的 201 名女性和 1993 年至 2007 年期间接受 FP 的 44 名癌症患者。结果包括人口统计学资料；跨性别队列中的抑郁、焦虑、身体意象、QOL 的验证量表（见下文）；所有三个队列中的 DRS 评分。
在参与的 29 名跨性别个体中，10 名 BA 女性（62%）和 12 名 BA 男性（92%）接受了 FP。贝克抑郁量表 II、医院焦虑和抑郁量表、跨性别者身体意象量表、生活满意度量表、简明健康调查 36 项量表和 DRS 评分在接受 FP 和拒绝 FP 的跨性别个体之间没有显著差异。在单变量模型中，接受 FP 的跨性别个体的后悔程度明显低于未接受 FP 的个体（OR 0.118，p=0.03）。接受 FP 的 BA 女性和 BA 男性跨性别患者报告的 DRS 中位数评分分别为 5（均值 9）和 7.5（均值 15），与 cisgender 女性相比均无显著差异（p=0.97，p=0.25），彼此之间也无显著差异（p=0.43）。
在一组接受 FP 咨询的个体中，抑郁、焦虑、身体意象和 QOL 在接受 FP 和不接受 FP 的跨性别个体之间似乎相似，而选择 FP 的个体的后悔程度明显较低。FP 是跨性别个体的一种选择，与 cisgender 女性相比，后悔程度没有显著差异。
