Bintintan Vasile, Burz Claudia, Pintea Irena, Muntean Adriana, Deleanu Diana, Lupan Iulia, Samasca Gabriel
Department of Surgery 1, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Institute of Oncology "Prof. Ion Chiricuta", 400015 Cluj-Napoca, Romania.
Cancers (Basel). 2024 Jul 18;16(14):2574. doi: 10.3390/cancers16142574.
Extracellular vesicles, or EVs, are membrane-bound nanocompartments produced by tumor cells. EVs carry proteins and nucleic acids from host cells to target cells, where they can transfer lipids, proteomes, and genetic material to change the function of target cells. EVs serve as reservoirs for mobile cellular signals. The collection of EVs using less invasive processes has piqued the interest of many researchers. Exosomes carry substances that can suppress the immune system. If the results of exosome screening are negative, immunotherapy will be beneficial for GC patients. In this study, we provide an update on EVs and GC based on ongoing review papers and clinical trials.
细胞外囊泡（EVs）是肿瘤细胞产生的膜结合纳米隔室。EVs将蛋白质和核酸从宿主细胞携带到靶细胞，在那里它们可以转移脂质、蛋白质组和遗传物质以改变靶细胞的功能。EVs充当移动细胞信号的储存库。使用侵入性较小的方法收集EVs引起了许多研究人员的兴趣。外泌体携带可抑制免疫系统的物质。如果外泌体筛查结果为阴性，免疫疗法将对胃癌患者有益。在本研究中，我们基于正在进行的综述论文和临床试验，提供了关于EVs与胃癌的最新情况。
