Department of Anesthesiology and Perioperative medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, People's Hospital of Henan University, Zhengzhou, Henan Province, China.
CNS Neurosci Ther. 2024 Feb;30(2):e14553. doi: 10.1111/cns.14553.
In recent years, sevoflurane and isoflurane are the most popular anesthetics in general anesthesia for their safe, rapid onset, and well tolerant. Nevertheless, many studies reported their neurotoxicity among pediatric and aged populations. This effect is usually manifested as cognitive impairment such as perioperative neurocognitive disorders. The wide application of sevoflurane and isoflurane during general anesthesia makes their safety a major health concern. Evidence indicates that iron dyshomeostasis and ferroptosis may establish a role in neurotoxicity of sevoflurane and isoflurane. However, the mechanisms of sevoflurane- and isoflurane-induced neuronal injury were not fully understood, which poses a barrier to the treatment of its neurotoxicity. We, therefore, reviewed the current knowledge on mechanisms of iron dyshomeostasis and ferroptosis and aimed to promote a better understanding of their roles in sevoflurane- and isoflurane-induced neurotoxicity.
近年来，七氟醚和异氟醚因其安全、起效迅速、耐受性好而成为全身麻醉中最常用的麻醉剂。然而，许多研究报告称它们在儿科和老年人群中具有神经毒性。这种作用通常表现为认知障碍，如围手术期神经认知障碍。七氟醚和异氟醚在全身麻醉中的广泛应用使其安全性成为一个主要的健康关注点。有证据表明，铁代谢失衡和铁死亡可能在七氟醚和异氟醚的神经毒性中发挥作用。然而，七氟醚和异氟醚诱导神经元损伤的机制尚不完全清楚，这对其神经毒性的治疗构成了障碍。因此，我们综述了目前关于铁代谢失衡和铁死亡机制的知识，旨在促进对它们在七氟醚和异氟醚诱导的神经毒性中的作用的更好理解。
