Department of Cell Biology and Epigenetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Commun Biol. 2024 Feb 9;7(1):167. doi: 10.1038/s42003-024-05855-w.
Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.
准确完整地复制遗传信息是每个细胞分裂的基本过程。复制许可（licensing）是为无差错基因组复制奠定基础的第一步。在复制许可过程中，微染色体维持蛋白复合物（minichromosome maintenance protein complexes），即 DNA 复制的分子马达，被加载到称为复制起点（replication origins）的基因组位点上。正确数量和功能的复制起点对于防止与严重疾病（包括癌症）相关的基因组不稳定性是必要的。在这里，我们深入探讨了最近的发现，这些发现揭示了复制起点的新功能、维持它们所需的途径以及它们对癌症治疗的影响。
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